Sigrid Nordang Skårn1, Heidi B Eggesbø2, Arnljot Flaa3, Sverre E Kjeldsen4, Morten Rostrup5, Cathrine Brunborg6, Henrik M Reims7, Tonje Amb Aksnes8. 1. Section of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway; Department of Acute Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: sigridnordang@yahoo.no. 2. Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway. 3. Section of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway; Department of Cardiology, Oslo University Hospital, Oslo, Norway. 4. Section of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital, Oslo, Norway. 5. Section of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway; Department of Acute Medicine, Oslo University Hospital, Oslo, Norway. 6. Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway. 7. Department of Pathology, Oslo University Hospital, Oslo, Norway. 8. Section of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway; Section for Interventional Cardiology, Department of Cardiology, Heart-, Lung-, and Vascular-Disease Clinic, Oslo University Hospital, Oslo, Norway.
Abstract
BACKGROUND: Abdominal adipose tissue (AAT) consists of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), which can be further divided into superficial and deep SAT. Despite being a key factor in the development of metabolic and cardiovascular diseases, what predicts future amount of AAT is largely unknown. OBJECTIVE: To determine long-term predictors of amount of AAT. METHODS: This was a mean 18-year follow-up study of a cohort of 94 healthy young Caucasian men, with and without a family history of diabetes (FHD). Cardiovascular risk markers were examined both at baseline and at follow-up. At follow-up, computed tomography (CT) of AAT was conducted to assess amount of superficial and deep SAT, and VAT. RESULTS: In multiple regression analyses, baseline body mass index (BMI) remained a positive predictor of future amount of superficial and deep SAT, while high-density lipoprotein (HDL) cholesterol was a negative predictor of all three sub-compartments. Baseline risk markers were generally stronger predictors among men with FHD, than among men without. In addition, FHD had greater impact on amount of deep SAT and VAT, than on amount of superficial SAT. CONCLUSION: Our data suggest that the traditional cardiovascular risk markers BMI, HDL cholesterol and family history of diabetes are long-term predictors of the different abdominal adipose tissue compartments from young towards middle age in healthy men. In men with family history of diabetes, cardiovascular risk markers at a young age seem to be of greater importance to future amount of abdominal adipose tissue, than among men without.
BACKGROUND: Abdominal adipose tissue (AAT) consists of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), which can be further divided into superficial and deep SAT. Despite being a key factor in the development of metabolic and cardiovascular diseases, what predicts future amount of AAT is largely unknown. OBJECTIVE: To determine long-term predictors of amount of AAT. METHODS: This was a mean 18-year follow-up study of a cohort of 94 healthy young Caucasian men, with and without a family history of diabetes (FHD). Cardiovascular risk markers were examined both at baseline and at follow-up. At follow-up, computed tomography (CT) of AAT was conducted to assess amount of superficial and deep SAT, and VAT. RESULTS: In multiple regression analyses, baseline body mass index (BMI) remained a positive predictor of future amount of superficial and deep SAT, while high-density lipoprotein (HDL) cholesterol was a negative predictor of all three sub-compartments. Baseline risk markers were generally stronger predictors among men with FHD, than among men without. In addition, FHD had greater impact on amount of deep SAT and VAT, than on amount of superficial SAT. CONCLUSION: Our data suggest that the traditional cardiovascular risk markers BMI, HDL cholesterol and family history of diabetes are long-term predictors of the different abdominal adipose tissue compartments from young towards middle age in healthy men. In men with family history of diabetes, cardiovascular risk markers at a young age seem to be of greater importance to future amount of abdominal adipose tissue, than among men without.
Authors: Gavin Hamilton; Alexandra N Schlein; Michael S Middleton; Catherine A Hooker; Tanya Wolfson; Anthony C Gamst; Rohit Loomba; Claude B Sirlin Journal: J Magn Reson Imaging Date: 2016-08-29 Impact factor: 4.813
Authors: Lisa Jannicke Kjønigsen; Magnus Harneshaug; Ann-Monica Fløtten; Lena Korsmo Karterud; Kent Petterson; Grethe Skjolde; Heidi B Eggesbø; Harald Weedon-Fekjær; Hege Berg Henriksen; Peter M Lauritzen Journal: Eur Radiol Exp Date: 2019-10-30