Literature DB >> 26712262

Unexpected histopathologic result of a wide surgical excision of a bleeding lesion of the skin: a case of Merkel cell carcinoma of the leg.

G Cestaro, P Festa, A M Cricrì, M Antropoli, M Castriconi.   

Abstract

BACKGROUND: Merkel cell Carcinoma is a very rare primary cutaneous tumor that often looks like an innocuous and asymptomatic nodule or plaque of the skin, but with a very fast growing. It is also called neuroendocrine carcinoma of the skin or trabecular cancer. The main treatment is based on a local excision followed by radiotherapy or chemotherapy. The most common site of presentation of this lesion is head and neck (40-60%.) and it often occur in older men with immunological system dysfunction like HIV patients, cancer, severe infections and immunosuppression for transplantation.
METHODS: The authors report a case of a bleeding Merkel Cell Carcinoma of the right leg in a 83 years old man with HCV infection, chronic kidney disease and diabetes mellitus type 2 that required local excision.
RESULTS: Lesion was entirely removed and then patient was sent to oncologists. After two months from surgical excision, healing process is regular and without complications.
CONCLUSIONS: This type of tumor can be misdiagnosed and, if bleeding, it can represent a serious surgical emergency.

Entities:  

Mesh:

Year:  2015        PMID: 26712262      PMCID: PMC4711981          DOI: 10.11138/gchir/2015.36.5.231

Source DB:  PubMed          Journal:  G Chir        ISSN: 0391-9005


  26 in total

Review 1.  Merkel cell carcinoma of the skin.

Authors:  P T Tai; E Yu; J Tonita; J Gilchrist
Journal:  J Cutan Med Surg       Date:  2000-10       Impact factor: 2.092

2.  The standard of care for Merkel cell carcinoma should include adjuvant radiation and lymph node surgery.

Authors:  Anne Herbst; Harley A Haynes; Paul Nghiem
Journal:  J Am Acad Dermatol       Date:  2002-04       Impact factor: 11.527

3.  Merkel cell carcinoma: changing incidence trends.

Authors:  Nicole C Hodgson
Journal:  J Surg Oncol       Date:  2005-01-01       Impact factor: 3.454

4.  Recurrent and subsequently metastasizing Merkel cell carcinoma in a 7-year-old girl.

Authors:  C Schmid; A Beham; J Feichtinger; L Auböck; O Dietze
Journal:  Histopathology       Date:  1992-05       Impact factor: 5.087

Review 5.  Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases.

Authors:  H Medina-Franco; M M Urist; J Fiveash; M J Heslin; K I Bland; S W Beenken
Journal:  Ann Surg Oncol       Date:  2001-04       Impact factor: 5.344

Review 6.  Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases.

Authors:  P T Tai; E Yu; E Winquist; A Hammond; L Stitt; J Tonita; J Gilchrist
Journal:  J Clin Oncol       Date:  2000-06       Impact factor: 44.544

7.  Neuroendocrine differentiation in primary Merkel cell carcinoma--possible prognostic significance.

Authors:  Virve Koljonen; Caj Haglund; Erkki Tukiainen; Tom Böhling
Journal:  Anticancer Res       Date:  2005 Mar-Apr       Impact factor: 2.480

Review 8.  Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature.

Authors:  L Johansson; J Tennvall; M Akerman
Journal:  APMIS       Date:  1990-08       Impact factor: 3.205

9.  Neural crest origin of mammalian Merkel cells.

Authors:  Viktor Szeder; Milos Grim; Zdenek Halata; Maya Sieber-Blum
Journal:  Dev Biol       Date:  2003-01-15       Impact factor: 3.582

10.  Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies.

Authors:  R Moll; A Löwe; J Laufer; W W Franke
Journal:  Am J Pathol       Date:  1992-02       Impact factor: 4.307

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