| Literature DB >> 26712194 |
Shama Chaudhry1, Rubina Hussain1, Madiha Munir Zuberi2, Zehra Zaidi2.
Abstract
Primary fallopian tube carcinoma is rare and accounts for 0.14-1.8% of all malignancies of the female genital tract. It has been found to be associated with nulliparity and subfertility, as well as with pelvic inflammatory disease. High parity has been reported to be protective but not in our 3 cases. History of pregnancy and the use of oral contraceptives decrease the PFTC risk significantly in literature. PFTC has been described in high-risk breast-ovarian cancer families with germ-line BRCA-1 and BRCA-2 mutations. Symptoms are nonspecific and include abdominal pelvic pain, vaginal bleeding and watery discharge. However, diagnosis is rarely achieved pre-operative because of misleading imaging. In many cases, the diagnosis is made incidentally on histopathology after surgery for an un-related condition commonly being an ovarian carcinoma.Entities:
Keywords: PFTC (Primary fallopian tube carcinoma), CA-125 levels, EOC (Epithelial ovarian cancer), BRCA-1 and BRCA-2 mutations.
Mesh:
Substances:
Year: 2016 PMID: 26712194
Source DB: PubMed Journal: J Pak Med Assoc ISSN: 0030-9982 Impact factor: 0.781