Didier Debieuvre1, Jean-Philippe Oster2, Robert Riou3, Jacques Berruchon4, Antoine Levy5, Jean-Pierre Mathieu6, Patrick Dumont7, Etienne Leroy-Terquem8, Véronique Tizon-Couetil9, Francis Martin10, Michel Grivaux11. 1. Pneumology Department, Emile Muller Hospital, 20 Avenue du Docteur René Laennec, 68070 Mulhouse, France. Electronic address: debieuvred@ch-mulhouse.fr. 2. Pneumology Department, Colmar Civil Hospitals, 39 Avenue de la Liberté, 68024 Colmar Cedex, France. Electronic address: jeanphilippe.oster@ch-colmar.fr. 3. Pneumology Department, Valence General Hospital, 179 Avenue du Maréchal Juin, 26953 Valence, France. Electronic address: rriou@ch-valence.fr. 4. Pneumology Department, Departmental Hospital, Les Oudairies, 85925 La-Roche-sur-Yon, Cedex 9, France. Electronic address: jberruch@chd-vendee.fr. 5. Pneumology Department, Jacques Coeur Hospital, 145 Avenue François Mitterrand, CS30010, 18020 Bourges Cedex, France. Electronic address: antoine.levy@ch-bourges.fr. 6. Pneumology Department, Côte Basque Hospital, 13 Avenue de l'interne Jacques Loëb, BP 8, 64109 Bayonne Cedex, France. Electronic address: jpmathieu004@ch-cotebasque.fr. 7. Pneumology Department, Chauny Hospital, 94 Rue des Anciens Combattants dA.F.N. & T.O.M., 02303 Chauny, France. Electronic address: dr.dumont@ch-chauny.fr. 8. Pneumology Department, Meulan-Les Mureaux Intercommunal Hospital, 1 Rue du Fort, 78250 Meulan-en-Yvelines, France. Electronic address: etiennelt@hotmail.com. 9. Pneumology Department, Avranches-Granville Hospital, 849 Rue des Menneries, BP 629, 50406 Granville Cedex, France. Electronic address: veronique.tizon@ch-avranches-granville.fr. 10. Pneumology and Sleep Disorders Department, Compiègne-Noyon, Intercommunal Hospital, 8 Avenue Henri Adnot, BP 50029, 60321 Compiègne Cedex, France. Electronic address: f.martin@ch-compiegnenoyon.fr. 11. Pneumology Department, Hospital, 6-8 Rue Saint Fiacre, BP 218, 77104 Meaux Cedex, France. Electronic address: m-grivaux@ch-meaux.fr.
Abstract
OBJECTIVES: To evaluate the impact of epidemiological changes observed in 10 years in men with NSCLC on 1-year mortality; to compare prognosis factors of 1-year mortality according to gender. MATERIAL AND METHODS: The French College of General Hospital Respiratory Physicians conducted two prospective epidemiological multicentre studies at a 10-year interval (KBP-2000-CPHG and KBP-2010-CPHG). These studies included all adult patients with primary lung cancer histologically or cytologically diagnosed between 1(st) January and 31(st) December for the years 2000 and 2010, managed in the pneumology department of the participating hospitals. A standardised form was completed for each patient. A steering committee checked recruitment exhaustiveness. Vital status 1 year after diagnosis was collected. RESULTS: In 2000 and 2010 respectively, 137 and 104 centres included 3921 and 4597 men and 748 and 1486 women with NSCLC. In 2010 compared to 2000, male patients were older but had better performance status (PS); they were less frequently ever-smokers and heavy smokers; their cancer (usually diagnosed at advanced stage) was more often adenocarcinoma (p<0.0001). In 10 years, 1-year mortality has significantly decreased in men (from 61.2% to 56.6%, p<0.0001) and in women (from 58.1% to 50.9%, p<0.0001), but remained higher in men than in women leading to increased difference between men and women. Decreased 1-year mortality remained statistically significant after adjustment on age, PS, smoking, and histology (men: OR=0.81, 95% CI=0.73-0.90, p<0.0001; women: 0.71, 0.57-0.88, p<0.002). Active smoking was not a prognosis factor in men (OR=1.04, CI=0.79-1.37, p=0.78); age (>75 years) had less impact on mortality in men than in women (men: OR=1.43, CI=1.22-1.67, p ≤ 0.0001; women: OR=2.32, CI=1.71-3.15; p<0.0001). CONCLUSIONS: The improved 1-year survival in 2010 as compared with 2000 was independent of age, smoking, PS, and histology, suggesting that it reflected new treatment and strategy efficacy. One-year mortality remains higher in men than in women.
OBJECTIVES: To evaluate the impact of epidemiological changes observed in 10 years in men with NSCLC on 1-year mortality; to compare prognosis factors of 1-year mortality according to gender. MATERIAL AND METHODS: The French College of General Hospital Respiratory Physicians conducted two prospective epidemiological multicentre studies at a 10-year interval (KBP-2000-CPHG and KBP-2010-CPHG). These studies included all adult patients with primary lung cancer histologically or cytologically diagnosed between 1(st) January and 31(st) December for the years 2000 and 2010, managed in the pneumology department of the participating hospitals. A standardised form was completed for each patient. A steering committee checked recruitment exhaustiveness. Vital status 1 year after diagnosis was collected. RESULTS: In 2000 and 2010 respectively, 137 and 104 centres included 3921 and 4597 men and 748 and 1486 women with NSCLC. In 2010 compared to 2000, male patients were older but had better performance status (PS); they were less frequently ever-smokers and heavy smokers; their cancer (usually diagnosed at advanced stage) was more often adenocarcinoma (p<0.0001). In 10 years, 1-year mortality has significantly decreased in men (from 61.2% to 56.6%, p<0.0001) and in women (from 58.1% to 50.9%, p<0.0001), but remained higher in men than in women leading to increased difference between men and women. Decreased 1-year mortality remained statistically significant after adjustment on age, PS, smoking, and histology (men: OR=0.81, 95% CI=0.73-0.90, p<0.0001; women: 0.71, 0.57-0.88, p<0.002). Active smoking was not a prognosis factor in men (OR=1.04, CI=0.79-1.37, p=0.78); age (>75 years) had less impact on mortality in men than in women (men: OR=1.43, CI=1.22-1.67, p ≤ 0.0001; women: OR=2.32, CI=1.71-3.15; p<0.0001). CONCLUSIONS: The improved 1-year survival in 2010 as compared with 2000 was independent of age, smoking, PS, and histology, suggesting that it reflected new treatment and strategy efficacy. One-year mortality remains higher in men than in women.
Authors: Soumaya Ben Khedher; Monica Neri; Alexandra Papadopoulos; David C Christiani; Nancy Diao; Curtis C Harris; Susan Olivo-Marston; Ann G Schwartz; Michele Cote; Anita Koushik; Jack Siemiatycki; Maria Teresa Landi; Rayjean J Hung; John McLaughlin; Eric J Duell; Angeline S Andrew; Irene Orlow; Bernard J Park; Hermann Brenner; Kai-Uwe Saum; Angela C Pesatori; Isabelle Stücker Journal: Int J Cancer Date: 2017-05-10 Impact factor: 7.396
Authors: D Isla; M Majem; N Viñolas; A Artal; A Blasco; E Felip; P Garrido; J Remón; M Baquedano; J M Borrás; M Die Trill; R García-Campelo; O Juan; C León; P Lianes; F López-Ríos; L Molins; M Á Planchuelo; M Cobo; L Paz-Ares; J M Trigo; J de Castro Journal: Clin Transl Oncol Date: 2016-11-24 Impact factor: 3.405
Authors: Cecilia Radkiewicz; Paul William Dickman; Anna Louise Viktoria Johansson; Gunnar Wagenius; Gustaf Edgren; Mats Lambe Journal: PLoS One Date: 2019-06-27 Impact factor: 3.240
Authors: Clémence Legoupil; Didier Debieuvre; Aurelien Marabelle; Stefan Michiels; Raïssa Kapso; Benjamin Besse; Julia Bonastre Journal: ERJ Open Res Date: 2020-04-19