Literature DB >> 26711748

C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection.

Dongming Zhao1, Satoshi Fukuyama1, Yuko Sakai-Tagawa2, Emi Takashita3, Jason E Shoemaker1, Yoshihiro Kawaoka4.   

Abstract

New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26711748      PMCID： PMC4776003          DOI： 10.1128/AAC.02055-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

1.  Replication-incompetent influenza A viruses that stably express a foreign gene.

Authors:  Makoto Ozawa; Sylvia T Victor; Andrew S Taft; Shinya Yamada; Chengjun Li; Masato Hatta; Subash C Das; Emi Takashita; Satoshi Kakugawa; Eileen A Maher; Gabriele Neumann; Yoshihiro Kawaoka
Journal:  J Gen Virol       Date:  2011-08-31       Impact factor: 3.891

2.  High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses.

Authors:  Yipeng Sun; Kun Qin; Jingjing Wang; Juan Pu; Qingdong Tang; Yanxin Hu; Yuhai Bi; Xueli Zhao; Hanchun Yang; Yuelong Shu; Jinhua Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-28       Impact factor: 11.205

Review 3.  Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies.

Authors:  Jonathan Hsu; Nancy Santesso; Reem Mustafa; Jan Brozek; Yao Long Chen; Jessica P Hopkins; Adrienne Cheung; Gayane Hovhannisyan; Liudmila Ivanova; Signe A Flottorp; Ingvil Saeterdal; Arthur D Wong; Jinhui Tian; Timothy M Uyeki; Elie A Akl; Pablo Alonso-Coello; Fiona Smaill; Holger J Schünemann
Journal:  Ann Intern Med       Date:  2012-02-27       Impact factor: 25.391

4.  Influenza virus-host interactome screen as a platform for antiviral drug development.

Authors:  Tokiko Watanabe; Eiryo Kawakami; Jason E Shoemaker; Tiago J S Lopes; Yukiko Matsuoka; Yuriko Tomita; Hiroko Kozuka-Hata; Takeo Gorai; Tomoko Kuwahara; Eiji Takeda; Atsushi Nagata; Ryo Takano; Maki Kiso; Makoto Yamashita; Yuko Sakai-Tagawa; Hiroaki Katsura; Naoki Nonaka; Hiroko Fujii; Ken Fujii; Yukihiko Sugita; Takeshi Noda; Hideo Goto; Satoshi Fukuyama; Shinji Watanabe; Gabriele Neumann; Masaaki Oyama; Hiroaki Kitano; Yoshihiro Kawaoka
Journal:  Cell Host Microbe       Date:  2014-11-20       Impact factor: 21.023

5.  Influenza A virus isolation, culture and identification.

Authors:  Amie J Eisfeld; Gabriele Neumann; Yoshihiro Kawaoka
Journal:  Nat Protoc       Date:  2014-10-16       Impact factor: 13.491

Review 6.  Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.

Authors:  Feng Wang; Christopher B Marshall; Mitsuhiko Ikura
Journal:  Cell Mol Life Sci       Date:  2013-01-11       Impact factor: 9.261

7.  H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet.

Authors:  Ying Zhang; Qianyi Zhang; Huihui Kong; Yongping Jiang; Yuwei Gao; Guohua Deng; Jianzhong Shi; Guobin Tian; Liling Liu; Jinxiong Liu; Yuntao Guan; Zhigao Bu; Hualan Chen
Journal:  Science       Date:  2013-05-02       Impact factor: 47.728

8.  Inhibition of enveloped viruses infectivity by curcumin.

Authors:  Tzu-Yen Chen; Da-Yuan Chen; Hsiao-Wei Wen; Jun-Lin Ou; Shyan-Song Chiou; Jo-Mei Chen; Min-Liang Wong; Wei-Li Hsu
Journal:  PLoS One       Date:  2013-05-01       Impact factor: 3.240

9.  A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.

Authors:  Dai Hatakeyama; Masaki Shoji; Seiya Yamayoshi; Takenori Hirota; Monami Nagae; Shin Yanagisawa; Masahiro Nakano; Naho Ohmi; Takeshi Noda; Yoshihiro Kawaoka; Takashi Kuzuhara
Journal:  J Biol Chem       Date:  2014-07-25       Impact factor: 5.157

10.  A comprehensive map of the influenza A virus replication cycle.

Authors:  Yukiko Matsuoka; Hiromi Matsumae; Manami Katoh; Amie J Eisfeld; Gabriele Neumann; Takeshi Hase; Samik Ghosh; Jason E Shoemaker; Tiago J S Lopes; Tokiko Watanabe; Shinji Watanabe; Satoshi Fukuyama; Hiroaki Kitano; Yoshihiro Kawaoka
Journal:  BMC Syst Biol       Date:  2013-10-02
View more
  9 in total

Review 1.  Histone modifiers at the crossroads of oncolytic and oncogenic viruses.

Authors:  Sara A Murphy; Norman John Mapes; Devika Dua; Balveen Kaur
Journal:  Mol Ther       Date:  2022-02-08       Impact factor: 12.910

2.  Identifying Small-Molecule Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Establishing a Fluorometric Assay.

Authors:  Xiaoming Bai; Hongmin Sun; Shuo Wu; Yuhuan Li; Lifei Wang; Bin Hong
Journal:  Front Immunol       Date:  2022-04-07       Impact factor: 8.786

3.  Comparative Proteomic Analysis of Lysine Acetylation in Fish CIK Cells Infected with Aquareovirus.

Authors:  Hong Guo; Jie Zhang; Yaping Wang; Chen Bu; Yanyan Zhou; Qin Fang
Journal:  Int J Mol Sci       Date:  2017-11-14       Impact factor: 5.923

4.  NF-κBp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone.

Authors:  Arunava Bandyopadhaya; Amy Tsurumi; Laurence G Rahme
Journal:  Front Microbiol       Date:  2017-06-30       Impact factor: 5.640

5.  The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells.

Authors:  Liqian Zhu; Xinyi Jiang; Xiaotian Fu; Yanhua Qi; Guoqiang Zhu
Journal:  Viruses       Date:  2018-09-27       Impact factor: 5.048

6.  Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication.

Authors:  Marta De Angelis; Donatella Amatore; Paola Checconi; Alessandra Zevini; Alessandra Fraternale; Mauro Magnani; John Hiscott; Giovanna De Chiara; Anna Teresa Palamara; Lucia Nencioni
Journal:  Front Cell Infect Microbiol       Date:  2022-01-06       Impact factor: 5.293

7.  Human N-Alpha-Acetyltransferase 60 Promotes Influenza A Virus Infection by Dampening the Interferon Alpha Signaling.

Authors:  Farjana Ahmed; Matloob Husain
Journal:  Front Immunol       Date:  2022-01-12       Impact factor: 7.561

8.  C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome.

Authors:  Xueming Xu; Jing Li; Xiuyan Long; Sifan Tao; Xiaoyu Yu; Xixian Ruan; Kai Zhao; Li Tian
Journal:  Front Pharmacol       Date:  2021-07-12       Impact factor: 5.810

9.  A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction.

Authors:  Y-H Taguchi; Turki Turki
Journal:  PLoS One       Date:  2020-09-11       Impact factor: 3.240
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.