| Literature DB >> 26711570 |
Murugesan Arumugam1, Varadarajan Parthasarathy2.
Abstract
Migraine is believed to be a chronic neurological disorder with the exact aetiology being unknown. But, there is a debate on the role of immune dysfunction in migraine pathophysiology. Hence, authors made a debut attempt to explore the link between lymphocyte subset populations and migraine. A significant increase in CD4(+) and decrease in CD8(+) population were observed in migraine patients compared to healthy volunteers. Interestingly, the immunoregulator CD4(+)CD25(+) levels were less in migraine patients compared to the healthy volunteers. The results of the present study indicate that failure of immunoregulation could be implicated in the pathophysiology of migraine.Entities:
Keywords: Autoimmunity; CD4(+); CD4(+)D25(+); CD4:CD8 ratio; CD8(+); Migraine
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Year: 2015 PMID： 26711570 DOI： 10.1016/j.jneuroim.2015.11.015
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478