| Literature DB >> 26711149 |
Jingqiu Dai1, Stephen M Parrish1, Wesley Y Yoshida1, M L Richard Yip2, James Turkson2, Michelle Kelly3, Philip Williams4.
Abstract
Seven new bromotyrosine-derived metabolites, purpuramine M-N (1-2), araplysillin VII-XI (3-7) and six known compounds (8-13) were isolated from an Indonesian sponge belonging to the family Aplysinellidae (Order Verongiida). The structures of the new compounds were determined by extensive NMR experiments and mass spectrometric measurements. These compounds were screened against BACE1 and five cancer cell lines.Entities:
Keywords: Aplysinellidae; BACE1 inhibitors; Bromotyrosine-derivatives; Cell viability; Verongiida
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Year: 2015 PMID: 26711149 PMCID: PMC4706807 DOI: 10.1016/j.bmcl.2015.11.086
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN: 0960-894X Impact factor: 2.823