Jingqiu Dai1, Stephen M Parrish1, Wesley Y Yoshida1, M L Richard Yip2, James Turkson2, Michelle Kelly3, Philip Williams4. 1. Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, United States. 2. University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. 3. Coasts and Oceans National Centre, National Institute of Water and Atmospheric Research, Auckland, New Zealand. 4. Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, United States; University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. Electronic address: philipwi@hawaii.edu.
Abstract
Seven new bromotyrosine-derived metabolites, purpuramine M-N (1-2), araplysillin VII-XI (3-7) and six known compounds (8-13) were isolated from an Indonesian sponge belonging to the family Aplysinellidae (Order Verongiida). The structures of the new compounds were determined by extensive NMR experiments and mass spectrometric measurements. These compounds were screened against BACE1 and five cancer cell lines.
Seven new bromotyrosine-derived metabolites, n class="Chemical">purpuramine M-N (1-2), araplysillin VII-XI (3-7) and six known compounds (8-13) were isolated from an Indonesian sponge belonging to the family Aplysinellidae (Order Verongiida). The structures of the new compounds were determined by extensive NMR experiments and mass spectrometric measurements. These compounds were screened against BACE1 and five cancer cell lines.
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