| Literature DB >> 26711143 |
Xuefeng Zhou1, Wei Fang2, Suiyi Tan3, Xiuping Lin1, Tianrong Xun3, Bingjie Yang4, Shuwen Liu5, Yonghong Liu6.
Abstract
Two new 2-benzylpyridin-4-one containing metabolites, aspernigrins C (3) and D (4), together with six known compounds (1, 2, and 5-8), were isolated from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. The structures of the new compounds were determined by NMR, MS, and optical rotation analyses. All the isolated compounds were evaluated for their inhibitory activities against infection with HIV-1 SF162 in TZM-bl cells. Malformin C (5) showed the strongest anti-HIV-1 activity with IC50 of 1.4±0.06μM (selectivity index, 11.4), meanwhile aspernigrin C (3) also exhibited potent activity with IC50 of 4.7±0.4μM (selectivity index, 7.5).Entities:
Keywords: Aspergillus niger; Aspernigrins; HIV-1 SF162; Malformin C
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Year: 2015 PMID： 26711143 DOI： 10.1016/j.bmcl.2015.12.005
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823