PURPOSE OF REVIEW: Cytomegalovirus (CMV) is the most common cause of congenital infection in the world. Symptomatic infants are at increased risk of developing permanent sequelae, including sensorineural hearing loss and neurodevelopmental delay. Advances in the treatment and prevention of congenital CMV infection are a high priority nationally and globally. RECENT FINDINGS: In symptomatic infants, antiviral therapy with 6 months of oral valganciclovir improves hearing and neurodevelopmental outcomes. Strategies to prevent congenital or maternal CMV infections, including the use of CMV hyperimmune globulin and development of a maternal vaccine, have yet to yield positive results. SUMMARY: The clinical significance of congenital CMV infection, developments in antiviral therapy, and efforts to prevent congenital disease are herein reviewed.
PURPOSE OF REVIEW: Cytomegalovirus (CMV) is the most common cause of congenital infection in the world. Symptomatic infants are at increased risk of developing permanent sequelae, including sensorineural hearing loss and neurodevelopmental delay. Advances in the treatment and prevention of congenital CMV infection are a high priority nationally and globally. RECENT FINDINGS: In symptomatic infants, antiviral therapy with 6 months of oral valganciclovir improves hearing and neurodevelopmental outcomes. Strategies to prevent congenital or maternal CMV infections, including the use of CMV hyperimmune globulin and development of a maternal vaccine, have yet to yield positive results. SUMMARY: The clinical significance of congenital CMV infection, developments in antiviral therapy, and efforts to prevent congenital disease are herein reviewed.
Authors: Shannon A Ross; Amina Ahmed; April L Palmer; Marian G Michaels; Pablo J Sánchez; David I Bernstein; Robert W Tolan; Zdenek Novak; Nazma Chowdhury; Karen B Fowler; Suresh B Boppana Journal: J Infect Dis Date: 2014-05-05 Impact factor: 5.226
Authors: Laura Patricia Stadler; David I Bernstein; S Todd Callahan; Christine B Turley; Flor M Munoz; Jennifer Ferreira; Mekhala Acharya; Gina A Gorgone Simone; Shital M Patel; Kathryn M Edwards; Susan L Rosenthal Journal: J Pediatric Infect Dis Soc Date: 2012-08-03 Impact factor: 3.164
Authors: Sara Ornaghi; Lawrence S Hsieh; Angélique Bordey; Patrizia Vergani; Michael J Paidas; Anthony N van den Pol Journal: J Neurosci Date: 2017-06-19 Impact factor: 6.167