R Arias-Ortega1, J C Echeverría2, M Guzmán-Huerta3, L Camargo-Marín3, M J Gaitán-González4, H Borboa-Olivares3, E Portilla-Islas5, S Camal-Ugarte6, C Vargas-García6, M R Ortiz2, R González-Camarena7. 1. Laboratorio de Investigación en Fisiología Humana (LIFH), Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana Unidad Iztapalapa (UAM-I), 09340 México D.F., México; Programa de Doctorado en Ingeniería Biomédica, División de Ciencias Básicas e Ingeniería, UAM-I, 09340 México D.F., México. Electronic address: ronald.arias@gmail.com. 2. Ingeniería de Fenómenos Fisiológicos Perinatales, Departamento de Ingeniería Eléctrica, UAM-I, 09340 México D.F., México. 3. Unidad de Investigación de Medicina Materno Fetal, del Departamento de Medicina Fetal del Instituto Nacional de Perinatología (INPer), 11000 México D.F., México. 4. Laboratorio de Investigación en Fisiología Humana (LIFH), Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana Unidad Iztapalapa (UAM-I), 09340 México D.F., México. 5. Programa de Doctorado en Ingeniería Biomédica, División de Ciencias Básicas e Ingeniería, UAM-I, 09340 México D.F., México. 6. Centro de Investigación Materno Infantil del Grupo de Estudios al Nacimiento (CIMIGen), 09890 México D.F., México. 7. Laboratorio de Investigación en Fisiología Humana (LIFH), Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana Unidad Iztapalapa (UAM-I), 09340 México D.F., México. Electronic address: rgc@xanum.uam.mx.
Abstract
BACKGROUND: The autonomic behavior of growth-restricted fetuses at different evolving hemodynamic stages has not been fully elicited. AIM: To analyze the respiratory sinus arrhythmia (RSA) of growth-restricted fetuses that despite this severe condition show normal Doppler hemodynamics. SUBJECTS: 10 growth-restricted fetuses (FGR group) with normal arterial pulsatility indices (umbilical, uterine, middle cerebral, ductus venosus and aortic isthmus), and 10 healthy fetuses (Control group), 32-37weeks of gestation. METHOD: B-mode ultrasound images for visualizing fetal breathing movements (FBM) or breathing akinesis (FBA), and the simultaneous RR-interval time series from maternal abdominal ECG recordings were obtained. The root-mean-square of successive differences of RR-intervals (RMSSD) was considered as a RSA-related parameter among the instantaneous amplitude of the high-frequency component (AMPHF) and its corresponding instantaneous frequency (IFHF), both computed by using empirical mode decomposition. Mean fetal heart-periods and RSA-related parameters were assessed during episodes of FBM and FBA in 30s length windows. RESULTS: FGR and Control groups presented RSA-related fluctuations during FBM and FBA. Also, both groups showed significant higher (p<0.001) values for the mean heart-period, RMSSD and AMPHF during FBM. No-significant differences (p>0.05) were found for the IFHF regardless of breathing activity (FBM vs. FBA). CONCLUSION: Growth-restricted fetuses without evident hemodynamic compromise exhibit a preserved autonomic cardiovascular regulation, characterized by higher values of RSA and mean heart-period in the presence of FBM. This physiological response reflects a compensatory strategy that may contribute to preserve blood flow redistribution to vital organs.
BACKGROUND: The autonomic behavior of growth-restricted fetuses at different evolving hemodynamic stages has not been fully elicited. AIM: To analyze the respiratory sinus arrhythmia (RSA) of growth-restricted fetuses that despite this severe condition show normal Doppler hemodynamics. SUBJECTS: 10 growth-restricted fetuses (FGR group) with normal arterial pulsatility indices (umbilical, uterine, middle cerebral, ductus venosus and aortic isthmus), and 10 healthy fetuses (Control group), 32-37weeks of gestation. METHOD: B-mode ultrasound images for visualizing fetal breathing movements (FBM) or breathing akinesis (FBA), and the simultaneous RR-interval time series from maternal abdominal ECG recordings were obtained. The root-mean-square of successive differences of RR-intervals (RMSSD) was considered as a RSA-related parameter among the instantaneous amplitude of the high-frequency component (AMPHF) and its corresponding instantaneous frequency (IFHF), both computed by using empirical mode decomposition. Mean fetal heart-periods and RSA-related parameters were assessed during episodes of FBM and FBA in 30s length windows. RESULTS: FGR and Control groups presented RSA-related fluctuations during FBM and FBA. Also, both groups showed significant higher (p<0.001) values for the mean heart-period, RMSSD and AMPHF during FBM. No-significant differences (p>0.05) were found for the IFHF regardless of breathing activity (FBM vs. FBA). CONCLUSION: Growth-restricted fetuses without evident hemodynamic compromise exhibit a preserved autonomic cardiovascular regulation, characterized by higher values of RSA and mean heart-period in the presence of FBM. This physiological response reflects a compensatory strategy that may contribute to preserve blood flow redistribution to vital organs.
Authors: Dirk Hoyer; Jan Żebrowski; Dirk Cysarz; Hernâni Gonçalves; Adelina Pytlik; Célia Amorim-Costa; João Bernardes; Diogo Ayres-de-Campos; Otto W Witte; Ekkehard Schleußner; Lisa Stroux; Christopher Redman; Antoniya Georgieva; Stephen Payne; Gari Clifford; Maria G Signorini; Giovanni Magenes; Fernando Andreotti; Hagen Malberg; Sebastian Zaunseder; Igor Lakhno; Uwe Schneider Journal: Physiol Meas Date: 2017-02-10 Impact factor: 2.833
Authors: Christopher W Jones; Kyle C Esteves; Sarah A O Gray; Tegan N Clarke; Keegan Callerame; Katherine P Theall; Stacy S Drury Journal: Psychoneuroendocrinology Date: 2019-03-22 Impact factor: 4.905