Yu Rang Park1, Jung Nyeo Chun2, Insuk So2, Hwa Jung Kim3, Seunghee Baek4, Ju-Hong Jeon5, Soo-Yong Shin6. 1. Office of Clinical Research Information, Asan Medical Center, Seoul, Republic of Korea. 2. Department of Physiology and Biomedical Sciences, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. 3. Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Seoul, Republic of Korea. 4. Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea. 5. Department of Physiology and Biomedical Sciences, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, Seoul, Republic of Korea jhjeon2@snu.ac.kr sooyong.shin@amc.seoul.kr. 6. Office of Clinical Research Information, Asan Medical Center, Seoul, Republic of Korea Department of Biomedical Informatics, Asan Medical Center, Seoul, Republic of Korea jhjeon2@snu.ac.kr sooyong.shin@amc.seoul.kr.
Abstract
BACKGROUND: Experimental evidence has suggested that transient receptor potential (TRP) channels play a crucial role in tumor biology. However, clinical relevance and significance of TRP channels in cancer remain largely unknown. MATERIALS AND METHODS: We applied a data-driven approach to dissect the expression landscape of 27 TRP channel genes in 14 types of human cancer using International Cancer Genome Consortium data. RESULTS: TRPM2 was found overexpressed in most tumors, whereas TRPM3 was broadly down-regulated. TRPV4 and TRPA1 were found up- and down-regulated respectively in a cancer type-specific manner. TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer. TRPM8 was identified as a new molecular marker for lung cancer diagnosis and TRPP1 for kidney cancer prognosis. CONCLUSION: Our data-driven approach demonstrates that the variation in the expression of TRP channel genes is manifested across various human cancer types and genes, for certain TRP channels have strong predictive diagnostic and prognostic potential. Copyright
BACKGROUND: Experimental evidence has suggested that transient receptor potential (TRP) channels play a crucial role in tumor biology. However, clinical relevance and significance of TRP channels in cancer remain largely unknown. MATERIALS AND METHODS: We applied a data-driven approach to dissect the expression landscape of 27 TRP channel genes in 14 types of humancancer using International Cancer Genome Consortium data. RESULTS:TRPM2 was found overexpressed in most tumors, whereas TRPM3 was broadly down-regulated. TRPV4 and TRPA1 were found up- and down-regulated respectively in a cancer type-specific manner. TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer. TRPM8 was identified as a new molecular marker for lung cancer diagnosis and TRPP1 for kidney cancer prognosis. CONCLUSION: Our data-driven approach demonstrates that the variation in the expression of TRP channel genes is manifested across various humancancer types and genes, for certain TRP channels have strong predictive diagnostic and prognostic potential. Copyright
Authors: Nobuaki Takahashi; Hsing-Yu Chen; Isaac S Harris; Daniel G Stover; Laura M Selfors; Roderick T Bronson; Thomas Deraedt; Karen Cichowski; Alana L Welm; Yasuo Mori; Gordon B Mills; Joan S Brugge Journal: Cancer Cell Date: 2018-05-24 Impact factor: 31.743
Authors: Lei Bao; Shu-Jen Chen; Kathleen Conrad; Kerry Keefer; Thomas Abraham; John P Lee; JuFang Wang; Xue-Qian Zhang; Iwona Hirschler-Laszkiewicz; Hong-Gang Wang; Sinisa Dovat; Brian Gans; Muniswamy Madesh; Joseph Y Cheung; Barbara A Miller Journal: J Biol Chem Date: 2016-09-30 Impact factor: 5.157