Literature DB >> 26708432

Preparation of a novel chitosan-g-poly(acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin.

Deepak Pathania1, Divya Gupta1, N C Kothiyal2, Gaurav Sharma3, G E Eldesoky4, Mu Naushad4.   

Abstract

Chitosan-g-poly(acrylamide)/Zn (CPA-Zn) nanocomposite was synthesized using simple method in the presence of microwave radiations. CPA-Zn nanocomposite was characterized by various analytical techniques. CPA-Zn nanocomposite was used for controlled drug delivery of ofloxacin. The maximum drug release was 75% which was observed in acidic medium. The cumulative drug release and drug released kinetics of CPA-Zn was investigated. It was noticed that the drug release behavior depended upon the pH of medium as well as on the the nature of matrix. CPA-Zn nanocomposites were also studied for their antibacterial activity against E. coli bacteria.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Acrylamide; Antibacterial; Chitosan; Drug delivery; Nanocomposite; Ofloxacin

Mesh：

Substances：

Year:  2015        PMID： 26708432     DOI： 10.1016/j.ijbiomac.2015.12.041

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  5 in total

1.  Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron.

Authors:  Gaurav Sharma; Mu Naushad; Bharti Thakur; Amit Kumar; Poonam Negi; Reena Saini; Anterpreet Chahal; Ashok Kumar; Florian J Stadler; U M H Aqil
Journal:  Int J Environ Res Public Health       Date:  2018-02-27       Impact factor: 3.390

2.  Construction of Chitosan-Zn-Based Electrochemical Biosensing Platform for Rapid and Accurate Assay of Actin.

Authors:  Chong Sun; Ye Zou; Daoying Wang; Zhiming Geng; Weimin Xu; Fang Liu; Jinxuan Cao
Journal:  Sensors (Basel)       Date:  2018-06-07       Impact factor: 3.576

3.  A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system.

Authors:  Yan Hu; Sheng Hu; Shangwen Zhang; Siyi Dong; Jie Hu; Li Kang; Xinzhou Yang
Journal:  Sci Rep       Date:  2021-04-28       Impact factor: 4.379

Review 4.  Chitosan as a Tool for Sustainable Development: A Mini Review.

Authors:  Soundouss Maliki; Gaurav Sharma; Amit Kumar; María Moral-Zamorano; Omid Moradi; Juan Baselga; Florian J Stadler; Alberto García-Peñas
Journal:  Polymers (Basel)       Date:  2022-04-05       Impact factor: 4.329

5.  Facile synthesis by a covalent binding reaction for pH-responsive drug release of carboxylated chitosan coated hollow mesoporous silica nanoparticles.

Authors:  Qiang Liu; Jiao Wang; Linnan Yang; Xiaofei Xia; Mei Wang; Shengguang Chen; Rongrong Zhu; Qingxiu Wang; Xianzheng Wu; Shilong Wang
Journal:  IET Nanobiotechnol       Date:  2018-06       Impact factor: 1.847
  5 in total

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