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Literature DB >> 26708292

NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions.

Abstract

NLRs (nucleotide-binding domain, leucine-rich repeat containing receptors) are pattern recognition receptors associated with immunity and inflammation in response to endogenous and exogenous pathogen and damage associated molecular patterns (PAMPs and DAMPs respectively). Dysregulated NLR function is associated with several diseases including cancers, metabolic diseases, autoimmune disorders and autoinflammatory syndromes. In the last decade, distinct cell and organ specific roles for NLRs have been identified however; their roles in cancer initiation, development and progression remain controversial. This review summarizes the emerging role of NLRs in cancer and their possible future as targets for cancer therapeutics.

Entities: Chemical

Keywords: ASC; Caspase; Inflammasomes; Innate immunity; Interleukins; Therapeutics; Tumor microenvironment

Mesh：

Substances：

Year: 2015 PMID： 26708292 DOI： 10.1007/s00018-015-2123-8

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.207

205 in total

1. Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.

Authors: A Gregory Sorensen; Kyrre E Emblem; Pavlina Polaskova; Dominique Jennings; Heisoog Kim; Marek Ancukiewicz; Meiyun Wang; Patrick Y Wen; Percy Ivy; Tracy T Batchelor; Rakesh K Jain
Journal: Cancer Res Date: 2011-11-29 Impact factor: 12.701

2. NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways.

Authors: E A Mercer; L Korhonen; Y Skoglösa; P A Olsson; J P Kukkonen; D Lindholm
Journal: EMBO J Date: 2000-07-17 Impact factor: 11.598

3. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury.

Authors: Juan Pablo de Rivero Vaccari; George Lotocki; Ofelia F Alonso; Helen M Bramlett; W Dalton Dietrich; Robert W Keane
Journal: J Cereb Blood Flow Metab Date: 2009-04-29 Impact factor: 6.200

4. Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.

Authors: Annalisa R Stone; William Bobo; Daniel J Brat; Nara S Devi; Erwin G Van Meir; Paula M Vertino
Journal: Am J Pathol Date: 2004-10 Impact factor: 4.307

5. Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy.

Authors: Mohd Shamshudin Watihayati; Hayati Fatemeh; Marzuki Marini; Amin Baig Atif; Wan Mohd Zahiruddin; Teguh Haryo Sasongko; Thean Hock Tang; Z A M H Zabidi-Hussin; Hisahide Nishio; Bin Alwi Zilfalil
Journal: Brain Dev Date: 2008-10-07 Impact factor: 1.961

6. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.

Authors: Mathias Chamaillard; Masahito Hashimoto; Yasuo Horie; Junya Masumoto; Su Qiu; Lisa Saab; Yasunori Ogura; Akiko Kawasaki; Koichi Fukase; Shoichi Kusumoto; Miguel A Valvano; Simon J Foster; Tak W Mak; Gabriel Nuñez; Naohiro Inohara
Journal: Nat Immunol Date: 2003-06-06 Impact factor: 25.606

7. The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex.

Authors: Frédéric Mille; Chantal Thibert; Joanna Fombonne; Nicolas Rama; Catherine Guix; Hideki Hayashi; Véronique Corset; John C Reed; Patrick Mehlen
Journal: Nat Cell Biol Date: 2009-05-24 Impact factor: 28.824

8. Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation.

Authors: Jieling Yang; Yue Zhao; Jianjin Shi; Feng Shao
Journal: Proc Natl Acad Sci U S A Date: 2013-08-12 Impact factor: 11.205

9. Epigenetic inactivation of TMS1/ASC in ovarian cancer.

Authors: Katsuhiko Terasawa; Satoru Sagae; Minoru Toyota; Kuniko Tsukada; Kazuhiro Ogi; Ayumi Satoh; Hiroaki Mita; Kohzoh Imai; Takashi Tokino; Ryuichi Kudo
Journal: Clin Cancer Res Date: 2004-03-15 Impact factor: 12.531

10. Neuronal apoptosis inhibitory protein is overexpressed in patients with unfavorable prognostic factors in breast cancer.

Authors: Jaewon Choi; Yu Kyeong Hwang; Young Jin Choi; Ki Eun Yoo; Jeong Han Kim; Seok Jin Nam; Jung Hyun Yang; Sang Jin Lee; Keon Hee Yoo; Ki Woong Sung; Hong Hoe Koo; Young Hyuck Im
Journal: J Korean Med Sci Date: 2007-09 Impact factor: 2.153

13 in total

1. NLR members in inflammation-associated carcinogenesis.

Authors: Ha Zhu; Xuetao Cao
Journal: Cell Mol Immunol Date: 2017-04-03 Impact factor: 11.530

Review 2. NLRs as Helpline in the Brain: Mechanisms and Therapeutic Implications.

Authors: Shalini Singh; Sushmita Jha
Journal: Mol Neurobiol Date: 2018-03-06 Impact factor: 5.590

3. SIRT1 was involved in TNF-α-promoted osteogenic differentiation of human DPSCs through Wnt/β-catenin signal.

Authors: Guijuan Feng; Ke Zheng; Donghui Song; Ke Xu; Dan Huang; Ye Zhang; Peipei Cao; Shuling Shen; Jinlong Zhang; Xingmei Feng; Dongmei Zhang
Journal: In Vitro Cell Dev Biol Anim Date: 2016-08-16 Impact factor: 2.416

Review 4. Comprehensive review of ASC structure and function in immune homeostasis and disease.

Authors: Ishan Agrawal; Sushmita Jha
Journal: Mol Biol Rep Date: 2020-03-02 Impact factor: 2.316

5. A regularized functional regression model enabling transcriptome-wide dosage-dependent association study of cancer drug response.

Authors: Evanthia Koukouli; Dennis Wang; Frank Dondelinger; Juhyun Park
Journal: PLoS Comput Biol Date: 2021-01-25 Impact factor: 4.475

Review 6. Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy.

Authors: Julia L Drewes; Franck Housseau; Cynthia L Sears
Journal: Br J Cancer Date: 2016-07-05 Impact factor: 7.640

Review 7. Inflammasome as a Therapeutic Target for Cancer Prevention and Treatment.

Authors: Huyen Trang Ha Thi; Suntaek Hong
Journal: J Cancer Prev Date: 2017-06-30

Review 8. Intestinal microbiota: a new force in cancer immunotherapy.

Authors: Zhujiang Dai; Jingqiu Zhang; Qi Wu; Huiwen Fang; Chunfeng Shi; Zhen Li; Chaobiao Lin; Dong Tang; Daorong Wang
Journal: Cell Commun Signal Date: 2020-06-10 Impact factor: 5.712

9. NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor.

Authors: Yuxian Wei; Hongyan Huang; Zhu Qiu; Hongzhong Li; Jinxiang Tan; Guosheng Ren; Xiaoyi Wang
Journal: Biomed Res Int Date: 2017-10-29 Impact factor: 3.411

10. NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway.

Authors: Xiao-Feng Yin; Qiong Zhang; Zhuo-Yu Chen; Hai-Fang Wang; Xin Li; Hong-Xia Wang; Hai-Xia Li; Chun-Min Kang; Shuai Chu; Kai-Fei Li; Yao Li; Yu-Rong Qiu
Journal: Int J Oncol Date: 2018-07-12 Impact factor: 5.650