Satomi Omotehara1,2, Mutsumi Nishida3,4, Megumi Satoh4,5, Mamiko Inoue3,4, Yusuke Kudoh3,4, Tatsunori Horie4,5, Akihiro Homma6, Yuji Nakamaru6, Kanako C Hatanaka7, Chikara Shimizu3. 1. Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan. satomi_omote@yahoo.co.jp. 2. Diagnostic Center for Sonography, Hokkaido University Hospital, Sapporo, Japan. satomi_omote@yahoo.co.jp. 3. Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan. 4. Diagnostic Center for Sonography, Hokkaido University Hospital, Sapporo, Japan. 5. Department of Radiological Technology, Hokkaido University Hospital, Sapporo, Japan. 6. Department of Otolaryngology, Hokkaido University Hospital, Sapporo, Japan. 7. Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
Abstract
PURPOSE: We evaluated the sonographic findings of immunoglobulin G4-related sclerosing sialadenitis (IgG4-SS). METHODS: Nineteen patients with IgG4-SS and 12 healthy volunteers (controls) were enrolled. The following sonographic features were evaluated: (1) enlargement of the submandibular gland by measurement of the longitudinal diameter and thickness; (2) the contour texture of the submandibular gland (smooth or rough); (3) the internal echo texture, categorized into three sonographic patterns (homogeneous, multiple hypoechoic nodule, and diffuse hypoechoic); and (4) quantitative color Doppler signaling. RESULTS: The longitudinal diameter and the thickness (mean ± SD) of the submandibular gland were significantly greater in patients than in controls (p = 0.005 and p < 0.001, respectively). Contour roughness was seen in 62.9 and 8.3 % of patients and controls (p < 0.001), respectively. Homogeneous echo textures alone were seen in controls, whereas multiple hypoechoic nodule patterns were seen in 60 % of the patients, and diffuse hypoechoic patterns were seen in 40 %. Color Doppler signaling (mean ± SD) was significantly higher in patients as compared with controls (p < 0.001). CONCLUSION: Patients could be distinguished from healthy volunteers using four distinctive sonographic findings, suggesting that ultrasonography would be a useful diagnostic tool for IgG4-SS.
PURPOSE: We evaluated the sonographic findings of immunoglobulin G4-related sclerosing sialadenitis (IgG4-SS). METHODS: Nineteen patients with IgG4-SS and 12 healthy volunteers (controls) were enrolled. The following sonographic features were evaluated: (1) enlargement of the submandibular gland by measurement of the longitudinal diameter and thickness; (2) the contour texture of the submandibular gland (smooth or rough); (3) the internal echo texture, categorized into three sonographic patterns (homogeneous, multiple hypoechoic nodule, and diffuse hypoechoic); and (4) quantitative color Doppler signaling. RESULTS: The longitudinal diameter and the thickness (mean ± SD) of the submandibular gland were significantly greater in patients than in controls (p = 0.005 and p < 0.001, respectively). Contour roughness was seen in 62.9 and 8.3 % of patients and controls (p < 0.001), respectively. Homogeneous echo textures alone were seen in controls, whereas multiple hypoechoic nodule patterns were seen in 60 % of the patients, and diffuse hypoechoic patterns were seen in 40 %. Color Doppler signaling (mean ± SD) was significantly higher in patients as compared with controls (p < 0.001). CONCLUSION:Patients could be distinguished from healthy volunteers using four distinctive sonographic findings, suggesting that ultrasonography would be a useful diagnostic tool for IgG4-SS.
Authors: Jan Laco; Ales Ryska; Petr Celakovsky; Helena Dolezalova; Radovan Mottl; Lubos Tucek Journal: Histopathology Date: 2011-03-25 Impact factor: 5.087
Authors: Eustáquio A Resende; Nathália R Gomes; Lucas G Abreu; Mauricio A A Castro; Maria C F Aguiar Journal: Dentomaxillofac Radiol Date: 2021-11-23 Impact factor: 3.525