Uterine leiomyomas with lymphoid infiltration simulating lymphoma. A report of seven cases.

Seven women, 35-50 years of age, had uterine leiomyomas with lymphoid infiltration. The leiomyomas ranged from 2 to 12 cm in greatest dimension and contained a variably dense infiltrate of small lymphocytes with scattered larger lymphoid cells and occasionally, numerous plasma cells; germinal centers were identified in some cases and ranged from large and florid to inconspicuous; rarely, eosinophils were present. Most of the tumors contained focal to extensive areas of sclerosis. In all the cases in which adjacent myometrium was available for examination, the lymphoid infiltrate was confined to the leiomyoma or was present to only a minor extent in the adjacent myometrium. Significant lymphoid infiltration of uterine leiomyomas, which appears to be a reactive process, has not been described previously. The polymorphous nature of the infiltrate and its confinement to the leiomyoma distinguish it from malignant lymphoma.