Michael Lardas1, Fiona Stewart2, Duncan Scrimgeour1, Fabian Hofmann3, Lorenzo Marconi4, Saeed Dabestani5, Axel Bex6, Alessandro Volpe7, Steven E Canfield8, Michael Staehler9, Milan Hora10, Thomas Powles11, Axel S Merseburger12, Markus A Kuczyk13, Karim Bensalah14, Peter F A Mulders15, Börje Ljungberg16, Thomas B L Lam17. 1. Department of Urology, Aberdeen Royal Infirmary, Aberdeen, UK. 2. Academic Urology Unit, University of Aberdeen, Aberdeen, UK. 3. Department of Urology, Sunderby Hospital, Sunderby, Sweden. 4. Department of Urology, Coimbra University Hospital, Coimbra, Portugal. 5. Department of Urology, Skåne University Hospital, Malmö, Sweden. 6. Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 7. Division of Urology, Maggiore della Carita' Hospital, University of Eastern Piedmont, Novara, Italy. 8. Division of Urology, University of Texas Medical School at Houston, Houston, TX, USA. 9. Department of Urology, Ludwig-Maximilians University, Munich, Germany. 10. Department of Urology, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Prague, Czech Republic. 11. The Royal Free NHS Trust and Barts Cancer Institute, Queen Mary University of London, London, UK. 12. Department of Urology, University Hospital Schleswig-Holstein, Lübeck, Germany. 13. Department of Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany. 14. Department of Urology, University of Rennes, Rennes, France. 15. Department of Urology, Radboud University Medical Centre, Nijmegen, The Netherlands. 16. Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden. 17. Department of Urology, Aberdeen Royal Infirmary, Aberdeen, UK; Academic Urology Unit, University of Aberdeen, Aberdeen, UK. Electronic address: thomasbllam@abdn.ac.uk.
Abstract
CONTEXT: Overall, 4-10% of patients with renal cell carcinoma (RCC) present with venous tumour thrombus. It is uncertain which surgical technique is best for these patients. Appraisal of outcomes with differing techniques would guide practice. OBJECTIVE: To systematically review relevant literature comparing the outcomes of different surgical therapies and approaches in treating vena caval thrombus (VCT) from nonmetastatic RCC. EVIDENCE ACQUISITION: Relevant databases (Medline, Embase, and the Cochrane Library) were searched to identify relevant comparative studies. Risk of bias and confounding assessments were performed. A narrative synthesis of the evidence was presented. EVIDENCE SYNTHESIS: The literature search identified 824 articles. Fourteen studies reporting on 2262 patients were included. No distinct surgical method was superior for the excision of VCT, although the method appeared to be dependent on tumour thrombus level. Minimal access techniques appeared to have better perioperative and recovery outcomes than traditional median sternotomy, but the impact on oncologic outcomes is unknown. Preoperative renal artery embolisation did not offer any oncologic benefits and instead resulted in significantly worse perioperative and recovery outcomes, including possibly higher perioperative mortality. The comparison of cardiopulmonary bypass versus no cardiopulmonary bypass showed no differences in oncologic outcomes. Overall, there were high risks of bias and confounding. CONCLUSIONS: The evidence base, although derived from retrospective case series and complemented by expert opinion, suggests that patients with nonmetastatic RCC and VCT and acceptable performance status should be considered for surgical intervention. Despite a robust review, the findings were associated with uncertainty due to the poor quality of primary studies available. The most efficacious surgical technique remains unclear. PATIENT SUMMARY: We examined the literature on the benefits of surgery to remove kidney cancers that have spread to neighbouring veins. The results suggest such surgery, although challenging and associated with high risk of complications, appears to be feasible and effective and should be contemplated for suitable patients if possible; however, many uncertainties remain due to the poor quality of the data.
CONTEXT: Overall, 4-10% of patients with renal cell carcinoma (RCC) present with venous tumour thrombus. It is uncertain which surgical technique is best for these patients. Appraisal of outcomes with differing techniques would guide practice. OBJECTIVE: To systematically review relevant literature comparing the outcomes of different surgical therapies and approaches in treating vena caval thrombus (VCT) from nonmetastatic RCC. EVIDENCE ACQUISITION: Relevant databases (Medline, Embase, and the Cochrane Library) were searched to identify relevant comparative studies. Risk of bias and confounding assessments were performed. A narrative synthesis of the evidence was presented. EVIDENCE SYNTHESIS: The literature search identified 824 articles. Fourteen studies reporting on 2262 patients were included. No distinct surgical method was superior for the excision of VCT, although the method appeared to be dependent on tumour thrombus level. Minimal access techniques appeared to have better perioperative and recovery outcomes than traditional median sternotomy, but the impact on oncologic outcomes is unknown. Preoperative renal artery embolisation did not offer any oncologic benefits and instead resulted in significantly worse perioperative and recovery outcomes, including possibly higher perioperative mortality. The comparison of cardiopulmonary bypass versus no cardiopulmonary bypass showed no differences in oncologic outcomes. Overall, there were high risks of bias and confounding. CONCLUSIONS: The evidence base, although derived from retrospective case series and complemented by expert opinion, suggests that patients with nonmetastatic RCC and VCT and acceptable performance status should be considered for surgical intervention. Despite a robust review, the findings were associated with uncertainty due to the poor quality of primary studies available. The most efficacious surgical technique remains unclear. PATIENT SUMMARY: We examined the literature on the benefits of surgery to remove kidney cancers that have spread to neighbouring veins. The results suggest such surgery, although challenging and associated with high risk of complications, appears to be feasible and effective and should be contemplated for suitable patients if possible; however, many uncertainties remain due to the poor quality of the data.
Authors: C Chahwan; P A Turcanu; F Alharbi; L Vaudreuil; A L Fiant; K Guleryuz; G Leon; X Tillou; A Doerfler Journal: Int Urol Nephrol Date: 2018-02-01 Impact factor: 2.370
Authors: Jun Ho Yang; Dae Hyun Song; Chunwoo Lee; Dong Hoon Kang; Jae Jun Jung; Sung Hwan Kim; Joung Hun Byun; Jong Woo Kim; Seong Ho Moon Journal: Medicine (Baltimore) Date: 2020-05 Impact factor: 1.889