Sevket Arslan1, Necdet Poyraz2, Ramazan Ucar3, Mihrican Yesildag4, Ahmet Yesildag2, Ahmet Zafer Caliskaner3. 1. Faculty of Medicine, Department of Internal Medicine, Division of Allergy and Immunology Diseases, Necmettin Erbakan University Meram, Konya, Turkey. sevketarslan77@hotmail.com. 2. Faculty of Medicine, Department of Radiology, Necmettin Erbakan University Meram, Konya, Turkey. 3. Faculty of Medicine, Department of Internal Medicine, Division of Allergy and Immunology Diseases, Necmettin Erbakan University Meram, Konya, Turkey. 4. Department of Chest Diseases, Konya Training and Research Hospital, Meram, Konya, Turkey.
Abstract
PURPOSE: In some primary immunodeficiency (PID) patients, especially in the subgroup with common variable immunodeficiency (CVID), radiosensitivity is a concern and avoidance of repeated radiation exposure has been recommended. To investigate the use of lung Magnetic resonance imaging (MRI) instead of Computed Tomography (CT) for the diagnosis and follow-up of various lesions in the lung parenchyma and airways, especially in PID patients in whom x-ray exposure should be limited. METHODS: The study enrolled 23 patients with PID who underwent thorax CT within the last 3 months and/or who will undergo initial radiological assessment. Lung MRI was performed in all patients to compare the pulmonary findings with CT images. RESULTS: MRI performance was weaker at detecting bronchiectasis extension, and a low concordance was found between MRI and CT in the assessment of the number of bronchial generations. CT better identified peripheral airway abnormalities, while CT and MRI gave similar results for detecting the presence and extension of consolidation, bullae, mucus plugging, bronchial wall thickening, bronchiectasis severity and nodules. CONCLUSIONS: Despite the low spatial resolution, higher cost, and low availability, we suggest MRI as a possible radiation-free alternative to CT in selected patients with PID.
PURPOSE: In some primary immunodeficiency (PID) patients, especially in the subgroup with common variable immunodeficiency (CVID), radiosensitivity is a concern and avoidance of repeated radiation exposure has been recommended. To investigate the use of lung Magnetic resonance imaging (MRI) instead of Computed Tomography (CT) for the diagnosis and follow-up of various lesions in the lung parenchyma and airways, especially in PID patients in whom x-ray exposure should be limited. METHODS: The study enrolled 23 patients with PID who underwent thorax CT within the last 3 months and/or who will undergo initial radiological assessment. Lung MRI was performed in all patients to compare the pulmonary findings with CT images. RESULTS: MRI performance was weaker at detecting bronchiectasis extension, and a low concordance was found between MRI and CT in the assessment of the number of bronchial generations. CT better identified peripheral airway abnormalities, while CT and MRI gave similar results for detecting the presence and extension of consolidation, bullae, mucus plugging, bronchial wall thickening, bronchiectasis severity and nodules. CONCLUSIONS: Despite the low spatial resolution, higher cost, and low availability, we suggest MRI as a possible radiation-free alternative to CT in selected patients with PID.
Authors: Juan C Baez; Pierluigi Ciet; Robert Mulkern; Ravi T Seethamraju; Edward Y Lee Journal: Magn Reson Imaging Clin N Am Date: 2015-05 Impact factor: 2.266
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