Dehao Yang1, Zhongqian Su1, Shengjie Wu2, Yong Bi3, Xiang Li1, Jia Li1, Kangliang Lou4, Hongyu Zhang5, Xu Zhang1. 1. a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 2. b Department of Cardiology, The Heart Center , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 3. c Department of Neurology , Zhejiang Provincial People's Hospital , Hangzhou , China. 4. d School of the First Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China , and. 5. e School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering , Wenzhou Medical University , Wenzhou , China.
Abstract
OBJECTIVE: Oxidative stress and low antioxidant status play a major role in the pathogenesis of inflammatory and autoimmune diseases. Myasthenia gravis (MG) is an autoimmune condition targeting the neuromuscular junction, and its antioxidant status is still controversial. Our study aimed to investigate the correlation between the clinical characteristics of MG and the serum antioxidant status of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine. MATERIALS AND METHODS: We measured serum antioxidant molecule levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine in 380 individuals, including 166 MG and 214 healthy controls. RESULTS: We found that MG patients had significantly lower serum levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine than healthy controls, whether male or female. Moreover, it was also shown in our study that uric acid, albumin and creatinine levels in patients with MG were correlated with disease activity and classifications performed by the Myasthenia Gravis Foundation of America. CONCLUSION: Our findings demonstrated that serum levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine were reduced in patients with MG. This suggested an active oxidative process in MG patients who had low antioxidant status.
OBJECTIVE: Oxidative stress and low antioxidant status play a major role in the pathogenesis of inflammatory and autoimmune diseases. Myasthenia gravis (MG) is an autoimmune condition targeting the neuromuscular junction, and its antioxidant status is still controversial. Our study aimed to investigate the correlation between the clinical characteristics of MG and the serum antioxidant status of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine. MATERIALS AND METHODS: We measured serum antioxidant molecule levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine in 380 individuals, including 166 MG and 214 healthy controls. RESULTS: We found that MGpatients had significantly lower serum levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine than healthy controls, whether male or female. Moreover, it was also shown in our study that uric acid, albumin and creatinine levels in patients with MG were correlated with disease activity and classifications performed by the Myasthenia Gravis Foundation of America. CONCLUSION: Our findings demonstrated that serum levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine were reduced in patients with MG. This suggested an active oxidative process in MGpatients who had low antioxidant status.
Authors: E Sally Ward; Deborah Gelinas; Erwin Dreesen; Jolien Van Santbergen; Jan Terje Andersen; Nicholas J Silvestri; Joseph E Kiss; Darrell Sleep; Daniel J Rader; John J P Kastelein; Els Louagie; Gestur Vidarsson; Isabel Spriet Journal: Front Immunol Date: 2022-06-01 Impact factor: 8.786
Authors: G Godoy; P B Travassos; M M Antunes; C C Iwanaga; A B Sá-Nakanishi; R Curi; J F Comar; R B Bazotte Journal: Braz J Med Biol Res Date: 2022-02-28 Impact factor: 2.590