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Literature DB >> 2670752

Human granulocyte chemotactic peptide (IL-8) as a specific neutrophil degranulator: comparison with other monokines.

J Willems¹, M Joniau, S Cinque, J van Damme.

Abstract

The influence of human monocyte-derived chemotactic peptide (GCP/IL-8) on degranulation of neutrophils was investigated in relation to that of other monokines. GCP/IL-8 promoted a dose-dependent release of lactoferrin from specific granules but had no effect on enzyme release from primary granules. From the other monokines that were tested, tumour necrosis factor alpha (TNF alpha) also induced degranulation, while IL-1 beta and IL-6 scored negatively. TNF alpha-induced lactoferrin release was enhanced by cytochalasin B pretreatment of the granulocytes, while GCP/IL-8-promoted degranulation was not. In contrast to GCP, TNF alpha also caused the release of LDH, suggesting a non-specific cell destruction. These observations further support the view that, unlike the other monokines, GCP/IL-8 is a true and specific granulocyte activator.

Entities: Chemical Disease Gene Species

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Year: 1989 PMID： 2670752 PMCID： PMC1385329

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

14 in total

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Journal: J Immunol Date: 1988-03-01 Impact factor: 5.422

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Journal: J Immunol Date: 1987-08-01 Impact factor: 5.422

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Journal: J Leukoc Biol Date: 1988-04 Impact factor: 4.962

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Authors: C G Larsen; A O Anderson; E Appella; J J Oppenheim; K Matsushima
Journal: Science Date: 1989-03-17 Impact factor: 47.728

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Journal: J Exp Med Date: 1988-04-01 Impact factor: 14.307

22 in total

1. Interleukin-8 (IL-8) is a major neutrophil chemotaxin from human alveolar macrophages stimulated with staphylococcal enterotoxin A (SEA).

Authors: E J Miller; S Nagao; F K Carr; J M Noble; A B Cohen
Journal: Inflamm Res Date: 1996-08 Impact factor: 4.575

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Authors: M O Osman; J U Kristensen; N O Jacobsen; S B Lausten; B Deleuran; M Deleuran; B Gesser; K Matsushima; C G Larsen; S L Jensen
Journal: Gut Date: 1998-08 Impact factor: 23.059

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Authors: S C Hsieh; H S Yu; S H Cheng; K J Li; M C Lu; C H Wu; C Y Tsai; C L Yu
Journal: Clin Rheumatol Date: 2006-03-31 Impact factor: 2.980

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Authors: B König; K E Jaeger; A E Sage; M L Vasil; W König
Journal: Infect Immun Date: 1996-08 Impact factor: 3.441

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Authors: A Wozniak; W H Betts; G A Murphy; M Rokicinski
Journal: Immunology Date: 1993-08 Impact factor: 7.397

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Journal: Am J Pathol Date: 1994-05 Impact factor: 4.307

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Authors: S Kotecha; B Chan; N Azam; M Silverman; R J Shaw
Journal: Arch Dis Child Fetal Neonatal Ed Date: 1995-03 Impact factor: 5.747