Literature DB >> 26707391

The synthesis and BK channel-opening activity of N-acylaminoalkyloxime derivatives of dehydroabietic acid.

Yong-Mei Cui1, Xin-Lan Liu2, Wen-Ming Zhang2, Hai-Xia Lin2, Tomohiko Ohwada3, Katsutoshi Ido4, Kohei Sawada4.   

Abstract

A series of N-acylaminoalkyloxime derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKα channels. The structure-activity relationship study revealed that a non-covalent interaction between the S atom of the 2-thiophene and the carbonyl O atom may contribute to conformation restriction for interaction with the ion channel. This research could guide the design and synthesis of novel abietane-based BK channel opener.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  BK channels; Dehydroabietic acid; Openers; Oxime

Mesh：

Substances：

Year:  2015        PMID： 26707391     DOI： 10.1016/j.bmcl.2015.12.038

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Synthesis and antitumor evaluation of (aryl)methyl-amine derivatives of dehydroabietic acid-based B ring-fused-thiazole as potential PI3K/AKT/mTOR signaling pathway inhibitors.

Authors:  Nai-Yuan Chen; Yu-Lan Xie; Guo-Dong Lu; Fang Ye; Xin-Yu Li; Yu-Wen Huang; Ming-Li Huang; Tie-Yu Chen; Cui-Ping Li
Journal:  Mol Divers       Date:  2020-04-15       Impact factor: 2.943

2.  Synthesis and Biological Evaluation of Novel Dehydroabietic Acid-Oxazolidinone Hybrids for Antitumor Properties.

Authors:  Xiu Wang; Fu-Hua Pang; Lin Huang; Xin-Ping Yang; Xian-Li Ma; Cai-Na Jiang; Fang-Yao Li; Fu-Hou Lei
Journal:  Int J Mol Sci       Date:  2018-10-11       Impact factor: 5.923

3.  Synthesis and In Vitro Anticancer Activity of Novel Dehydroabietic Acid-Based Acylhydrazones.

Authors:  Fang-Yao Li; Xiu Wang; Wen-Gui Duan; Gui-Shan Lin
Journal:  Molecules       Date:  2017-06-29       Impact factor: 4.411

4.  Synthesis and biological evaluation of novel N-(piperazin-1-yl)alkyl-1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential MEK inhibitors.

Authors:  Hao Chen; Chao Qiao; Ting-Ting Miao; A-Liang Li; Wen-Yan Wang; Wen Gu
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

Review 5.  Recent Advances on Biological Activities and Structural Modifications of Dehydroabietic Acid.

Authors:  Meng Hao; Jianwei Xu; Houpeng Wen; Jiawei Du; Shaoyong Zhang; Min Lv; Hui Xu
Journal:  Toxins (Basel)       Date:  2022-09-12       Impact factor: 5.075
  5 in total

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