K G Kahl1, A Kerling2, U Tegtbur2, E Gützlaff2, J Herrmann3, L Borchert3, Zeynep Ates3, M Westhoff-Bleck4, K Hueper5, D Hartung5. 1. Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School (MHH), Carl-Neuberg. Street 1, Hannover, Germany; Department of Neurology, MHH, Hannover, Germany. Electronic address: kahl.kai@mh-hannover.de. 2. Department of Neurology, MHH, Hannover, Germany; Institute of Sports Medicine, Hannover Medical School, Carl-Neuberg-Street 1, 30625 Hannover, Germany. 3. Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School (MHH), Carl-Neuberg. Street 1, Hannover, Germany; Department of Neurology, MHH, Hannover, Germany. 4. Department of Neurology, MHH, Hannover, Germany; Dep. of Cardiology and Angiology, MHH, Hannover, Germany. 5. Institute for Diagnostic and Interventional Radiology, MHH, Hannover, Germany; Department of Neurology, MHH, Hannover, Germany.
Abstract
OBJECTIVE:Major depressive disorder (MDD) is associated with increased amounts of intra-abdominal and epicardial adipose tissue, risk factors for the development of cardio-metabolic disorders. Exercise has been shown to reduce intra-abdominal fat in different conditions such as obesity and diabetes mellitus, thereby reducing cardio-metabolic risks. Therefore we examined the effects of exercise on adipose tissue compartments in patients with MDD. METHODS:Of thirty depressed patients included, twenty received supervised exercise training, and ten received no specific training. Volumes of subcutaneous, intra-abdominal and epicardial adipose tissue were measured using magnetic resonance imaging, and factors constituting the metabolic syndrome were determined. RESULTS: Significant effects of the training condition were observed on the amount of epicardial adipose tissue (P=0.017), subcutaneous adipose tissue (P=0.023), weight (P=0.047), body-mass index (P=0.04), high density lipoproteins (P=0.021) and the number of metabolic syndrome factors (P=0.018). The amount of intra-abdominal adipose tissue decreased slightly, although not significantly, in the exercise group. CONCLUSION:Exercise training reduces the amount of visceral, in particular epicardial adipose tissue, in patients with MDD, and ameliorates factors constituting the metabolic syndrome. Given the high prevalence of cardio-metabolic disorders in major depression, exercise training may be recommended as an additional treatment component.
RCT Entities:
OBJECTIVE: Major depressive disorder (MDD) is associated with increased amounts of intra-abdominal and epicardial adipose tissue, risk factors for the development of cardio-metabolic disorders. Exercise has been shown to reduce intra-abdominal fat in different conditions such as obesity and diabetes mellitus, thereby reducing cardio-metabolic risks. Therefore we examined the effects of exercise on adipose tissue compartments in patients with MDD. METHODS: Of thirty depressedpatients included, twenty received supervised exercise training, and ten received no specific training. Volumes of subcutaneous, intra-abdominal and epicardial adipose tissue were measured using magnetic resonance imaging, and factors constituting the metabolic syndrome were determined. RESULTS: Significant effects of the training condition were observed on the amount of epicardial adipose tissue (P=0.017), subcutaneous adipose tissue (P=0.023), weight (P=0.047), body-mass index (P=0.04), high density lipoproteins (P=0.021) and the number of metabolic syndrome factors (P=0.018). The amount of intra-abdominal adipose tissue decreased slightly, although not significantly, in the exercise group. CONCLUSION: Exercise training reduces the amount of visceral, in particular epicardial adipose tissue, in patients with MDD, and ameliorates factors constituting the metabolic syndrome. Given the high prevalence of cardio-metabolic disorders in major depression, exercise training may be recommended as an additional treatment component.
Authors: J Ruppert; D Hartung; M Westhoff-Bleck; J Herrmann; B Stubbs; J Cordes; T H C Krüger; R Lichtinghagen; K G Kahl Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-11-23 Impact factor: 5.270
Authors: Sven Haufe; Kai G Kahl; Arno Kerling; Gudrun Protte; Pauline Bayerle; Hedwig T Stenner; Simone Rolff; Thorben Sundermeier; Julian Eigendorf; Momme Kück; Alexander A Hanke; Katriona Keller-Varady; Ralf Ensslen; Lars Nachbar; Dirk Lauenstein; Dietmar Böthig; Christoph Terkamp; Meike Stiesch; Denise Hilfiker-Kleiner; Axel Haverich; Uwe Tegtbur Journal: Front Psychiatry Date: 2020-06-18 Impact factor: 4.157
Authors: Jenny Chum; Min Suk Kim; Laura Zielinski; Meha Bhatt; Douglas Chung; Sharon Yeung; Kathryn Litke; Kathleen McCabe; Jeff Whattam; Laura Garrick; Laura O'Neill; Stefanie Goyert; Colleen Merrifield; Yogita Patel; Zainab Samaan Journal: Evid Based Ment Health Date: 2017-10-22