Takahiro Uotani1,2, Mitsushige Sugimoto3, Hitomi Ichikawa4, Shingo Tanaka1,2, Hiroyuki Nagashima5, Tomohisa Uchida6, David Y Graham1, Yoshio Yamaoka1,2. 1. Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael DeBakey Veterans Affairs Medical Center, Houston, USA. 2. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Oita. 3. Division of Digestive Endoscopy, Shiga University of Medical Science Hospital, Otsu. 4. First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu. 5. Gastroenterological Medicine, Rumoi City Hospital, Rumoi. 6. Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Abstract
OBJECTIVES: Gastric cancer is etiologically related to interactions between Helicobacter pylori (H. pylori) infection, environmental and host factors. Gastric carcinoma is associated with a cascade of increasing atrophic gastric mucosal damage. Prostate stem cell antigen (PSCA) polymorphisms have been associated with an increased risk of gastric cancer. We aimed to examine the interaction between PSCA polymorphisms and H. pylori in the progression of H. pylori-related gastritis. METHODS: The genotypes (TT, TC and CC) of PSCA single nucleotide polymorphism rs2294008 among H. pylori infected and uninfected Bhutanese were compared with the severity of H. pylori-related gastritis [neutrophils, monocytes, atrophy scores, H. pylori density, and the presence and extent of intestinal metaplasia (IM)] using the updated Sydney system. RESULTS: Biopsies from 339 participants were included. The proportion of biopsies with IM was significantly (P < 0.05) greater in those with the TT genotype than in either those with the CT or CC genotype. Although no significant differences were found in inflammation or H. pylori density scores, the scores for IM at both gastric corpus and antrum among participants infected by H. pylori with the TT genotype was significantly (P < 0.05) greater than in the C allele carriers. CONCLUSION: PSCA TT genotype is associated with a more than a threefold increase in the prevalence and the extent of gastric mucosal IM compared to C allele carriers among H. pylori-infected Bhutanese.
OBJECTIVES:Gastric cancer is etiologically related to interactions between Helicobacter pylori (H. pylori) infection, environmental and host factors. Gastric carcinoma is associated with a cascade of increasing atrophic gastric mucosal damage. Prostate stem cell antigen (PSCA) polymorphisms have been associated with an increased risk of gastric cancer. We aimed to examine the interaction between PSCA polymorphisms and H. pylori in the progression of H. pylori-related gastritis. METHODS: The genotypes (TT, TC and CC) of PSCA single nucleotide polymorphism rs2294008 among H. pylori infected and uninfected Bhutanese were compared with the severity of H. pylori-related gastritis [neutrophils, monocytes, atrophy scores, H. pylori density, and the presence and extent of intestinal metaplasia (IM)] using the updated Sydney system. RESULTS: Biopsies from 339 participants were included. The proportion of biopsies with IM was significantly (P < 0.05) greater in those with the TT genotype than in either those with the CT or CC genotype. Although no significant differences were found in inflammation or H. pylori density scores, the scores for IM at both gastric corpus and antrum among participants infected by H. pylori with the TT genotype was significantly (P < 0.05) greater than in the C allele carriers. CONCLUSION:PSCA TT genotype is associated with a more than a threefold increase in the prevalence and the extent of gastric mucosal IM compared to C allele carriers among H. pylori-infected Bhutanese.
Authors: R E Reiter; Z Gu; T Watabe; G Thomas; K Szigeti; E Davis; M Wahl; S Nisitani; J Yamashiro; M M Le Beau; M Loda; O N Witte Journal: Proc Natl Acad Sci U S A Date: 1998-02-17 Impact factor: 11.205
Authors: Paul Lochhead; Bernd Frank; Georgina L Hold; Charles S Rabkin; Michael T H Ng; Thomas L Vaughan; Harvey A Risch; Marilie D Gammon; Jolanta Lissowska; Melanie N Weck; Elke Raum; Heiko Müller; Thomas Illig; Norman Klopp; Alan Dawson; Kenneth E McColl; Hermann Brenner; Wong-Ho Chow; Emad M El-Omar Journal: Gastroenterology Date: 2010-11-09 Impact factor: 22.682