Literature DB >> 26706410

Targeted nanosystems: Advances in targeted dendrimers for cancer therapy.

Hu Yang1.   

Abstract

Dendrimers possess discrete highly compact nanostructures constituted of successive branched layers. Soon after the inception of dendrimers, recognition of their tunable structures and biologically favorable properties provoked a great enthusiasm in delving deeply into the utility of dendrimers for biomedical and pharmaceutical applications. One of the most important nanotechnology applications is the development of nanomedicines for targeted cancer therapies. Tremendous success in targeted therapies has been achieved with the use of dendrimer-based nanomedicines. This article provides a concise review on latest advances in the utility of dendrimers in immunotherapies and hormone therapies. FROM THE CLINICAL EDITOR: Much basic and clinical research has been done since the invention of dendrimers, which are highly branched nano-sized molecules with the ability to act as carriers in nanomedicine. In this concise review article, the authors highlighted the current use of dendrimers in immunotherapies and hormone therapies in the fight against cancers.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Critical nanoscale design parameters; Dendrimer; Hormone therapy; Immunotherapy

Mesh:

Substances:

Year:  2015        PMID: 26706410      PMCID: PMC4789125          DOI: 10.1016/j.nano.2015.11.012

Source DB:  PubMed          Journal:  Nanomedicine        ISSN: 1549-9634            Impact factor:   5.307


  43 in total

Review 1.  Exploiting tumour hypoxia in cancer treatment.

Authors:  J Martin Brown; William R Wilson
Journal:  Nat Rev Cancer       Date:  2004-06       Impact factor: 60.716

2.  Dendrimer-triglycine-EGF nanoparticles for tumor imaging and targeted nucleic acid and drug delivery.

Authors:  Quan Yuan; Eunmee Lee; W Andrew Yeudall; Hu Yang
Journal:  Oral Oncol       Date:  2010-08-21       Impact factor: 5.337

Review 3.  Dendrimers in biomedical applications--reflections on the field.

Authors:  Sönke Svenson; Donald A Tomalia
Journal:  Adv Drug Deliv Rev       Date:  2005-11-21       Impact factor: 15.470

Review 4.  Adoptive immunotherapy for cancer: harnessing the T cell response.

Authors:  Nicholas P Restifo; Mark E Dudley; Steven A Rosenberg
Journal:  Nat Rev Immunol       Date:  2012-03-22       Impact factor: 53.106

5.  In vitro enzymatic stability of dendritic peptides.

Authors:  Hu Yang; Stephanie T Lopina
Journal:  J Biomed Mater Res A       Date:  2006-02       Impact factor: 4.396

6.  Overexpression of follicle-stimulating hormone receptor activates oncogenic pathways in preneoplastic ovarian surface epithelial cells.

Authors:  Jung-Hye Choi; Kyung-Chul Choi; Nelly Auersperg; Peter C K Leung
Journal:  J Clin Endocrinol Metab       Date:  2004-11       Impact factor: 5.958

Review 7.  Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.

Authors:  Michelle Longmire; Peter L Choyke; Hisataka Kobayashi
Journal:  Nanomedicine (Lond)       Date:  2008-10       Impact factor: 5.307

8.  Penicillin V-conjugated PEG-PAMAM star polymers.

Authors:  Hu Yang; Stephanie T Lopina
Journal:  J Biomater Sci Polym Ed       Date:  2003       Impact factor: 3.517

9.  Encapsulation and extended release of anti-cancer anastrozole by stealth nanoparticles.

Authors:  Kumkum Sarkar; Hu Yang
Journal:  Drug Deliv       Date:  2008-06       Impact factor: 6.419

10.  Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo.

Authors:  Saghir Akhtar; Bashayer Al-Zaid; Ahmed Z El-Hashim; Bindu Chandrasekhar; Sreeja Attur; Mariam H M Yousif; Ibrahim F Benter
Journal:  PLoS One       Date:  2015-07-13       Impact factor: 3.240

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  16 in total

1.  Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery.

Authors:  Leyuan Xu; Remy C Cooper; Juan Wang; W Andrew Yeudall; Hu Yang
Journal:  ACS Biomater Sci Eng       Date:  2017-06-21

2.  Improved intestinal absorption of water-soluble drugs by acetylation of G2 PAMAM dendrimer nanocomplexes in rat.

Authors:  Chengyun Yan; Jiwei Gu; Yuguang Lv; Weiguo Shi; Hongying Jing
Journal:  Drug Deliv Transl Res       Date:  2017-06       Impact factor: 4.617

3.  Fabrication and characterization of a folic acid-bound 5-fluorouracil loaded quantum dot system for hepatocellular carcinoma targeted therapy.

Authors:  Xiaoxin Shi; Dongxiu He; Guotao Tang; Qian Tang; Runde Xiong; Hu Ouyang; Cui-Yun Yu
Journal:  RSC Adv       Date:  2018-05-29       Impact factor: 4.036

Review 4.  Biomedical nanomaterials for immunological applications: ongoing research and clinical trials.

Authors:  Vincent Lenders; Xanthippi Koutsoumpou; Ara Sargsian; Bella B Manshian
Journal:  Nanoscale Adv       Date:  2020-08-24

Review 5.  Supramolecular metal-based nanoparticles for drug delivery and cancer therapy.

Authors:  Xiaomin Jiang; Chunbai He; Wenbin Lin
Journal:  Curr Opin Chem Biol       Date:  2021-02-22       Impact factor: 8.822

Review 6.  Preparing (Metalla)carboranes for Nanomedicine.

Authors:  Marta Gozzi; Benedikt Schwarze; Evamarie Hey-Hawkins
Journal:  ChemMedChem       Date:  2021-03-19       Impact factor: 3.466

7.  Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression.

Authors:  Kyla Walworth; Manish Bodas; Ryan John Campbell; Doug Swanson; Ajit Sharma; Neeraj Vij
Journal:  PLoS One       Date:  2016-07-19       Impact factor: 3.240

Review 8.  The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties.

Authors:  Donald A Tomalia; Linda S Nixon; David M Hedstrand
Journal:  Biomolecules       Date:  2020-04-21

9.  Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel.

Authors:  Liang Li; Na Liang; Danfeng Wang; Pengfei Yan; Yoshiaki Kawashima; Fude Cui; Shaoping Sun
Journal:  Int J Mol Sci       Date:  2018-10-12       Impact factor: 5.923

10.  Dendrimer-based selective autophagy-induction rescues ΔF508-CFTR and inhibits Pseudomonas aeruginosa infection in cystic fibrosis.

Authors:  Scott Mackenzie Brockman; Manish Bodas; David Silverberg; Ajit Sharma; Neeraj Vij
Journal:  PLoS One       Date:  2017-09-13       Impact factor: 3.240

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