Nazar Mazurak1,2, Helene Sauer1, Katja Weimer1, Dirk Dammann3, Stephan Zipfel1, Björn Horing4, Eric R Muth4, Martin Teufel1, Paul Enck1, Isabelle Mack1. 1. Department of Psychosomatic Medicine and Psychotherapy, University Medical Hospital, Tübingen, Germany. 2. SymbioGruppe GmbH, Herborn, Germany. 3. Fachkliniken Wangen I.A., Children Rehabilitation Hospital for Respiratory Diseases, Allergies and Psychosomatics, Wangen I.A., Germany. 4. Department of Psychology, Clemson University, Clemson, South Carolina, USA.
Abstract
OBJECTIVE: Autonomic dysregulation is a well-established feature in adults with obesity but not in children. Since this dysregulation could contribute to weight dynamics, this study aimed to compare autonomic regulation in children with obesity and normal-weight peers and to track autonomic status during weight reduction. METHODS: Sixty children with obesity and 27 age- and sex-matched normal-weight healthy participants were included. Heart rate variability (HRV) was assessed at baseline and during a mental stress test and a subsequent recovery period. Children with obesity were investigated both upon admission and discharge. RESULTS: Upon admission, no significant differences in HRV parameters were found for normal-weight participants and those with obesity. Inpatient treatment led to significant changes in HRV with increase in general variability (standard deviation of the normal-to-normal interval (SDNN), P < 0.001) as well as of parasympathetic regulation (root mean square successive difference (RMSSD) and high frequency power (logHF), P < 0.01). Children with obesity had sympathetic activation similar to normal-weight controls during mental stress with subsequent return to baseline values, and weight loss did not affect this profile. CONCLUSIONS: A weight reduction program induced a change in autonomic activity in children with obesity toward parasympathetic dominance but had no influence on autonomic nervous system reactivity during stress conditions.
OBJECTIVE: Autonomic dysregulation is a well-established feature in adults with obesity but not in children. Since this dysregulation could contribute to weight dynamics, this study aimed to compare autonomic regulation in children with obesity and normal-weight peers and to track autonomic status during weight reduction. METHODS: Sixty children with obesity and 27 age- and sex-matched normal-weight healthy participants were included. Heart rate variability (HRV) was assessed at baseline and during a mental stress test and a subsequent recovery period. Children with obesity were investigated both upon admission and discharge. RESULTS: Upon admission, no significant differences in HRV parameters were found for normal-weight participants and those with obesity. Inpatient treatment led to significant changes in HRV with increase in general variability (standard deviation of the normal-to-normal interval (SDNN), P < 0.001) as well as of parasympathetic regulation (root mean square successive difference (RMSSD) and high frequency power (logHF), P < 0.01). Children with obesity had sympathetic activation similar to normal-weight controls during mental stress with subsequent return to baseline values, and weight loss did not affect this profile. CONCLUSIONS: A weight reduction program induced a change in autonomic activity in children with obesity toward parasympathetic dominance but had no influence on autonomic nervous system reactivity during stress conditions.
Authors: Isabelle Mack; Nadine Reiband; Carolin Etges; Sabrina Eichhorn; Norbert Schaeffeler; Guido Zurstiege; Caterina Gawrilow; Katja Weimer; Riyad Peeraully; Martin Teufel; Gunnar Blumenstock; Katrin Elisabeth Giel; Florian Junne; Stephan Zipfel Journal: J Med Internet Res Date: 2020-04-24 Impact factor: 5.428
Authors: Katja Weimer; Helene Sauer; Bjoern Horing; Francesco Valitutti; Nazar Mazurak; Stephan Zipfel; Andreas Stengel; Paul Enck; Isabelle Mack Journal: Nutrients Date: 2018-05-31 Impact factor: 5.717
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