Theo G Seiler1, Isaak Fischinger2, Tobias Koller2, Viktor Derhartunian2, Theo Seiler2. 1. From the Institut für Refraktive und Ophthalmo-Chirurgie (T.G. Seiler, Fischinger, Koller, Derhartunian, T. Seiler), Zürich, Switzerland and the Klinik und Poliklinik für Augenheilkunde, Klinikum rechts der Isar (T.G. Seiler, Fischinger), Technische Universität München, München, Germany. Electronic address: theo@seiler.tv. 2. From the Institut für Refraktive und Ophthalmo-Chirurgie (T.G. Seiler, Fischinger, Koller, Derhartunian, T. Seiler), Zürich, Switzerland and the Klinik und Poliklinik für Augenheilkunde, Klinikum rechts der Isar (T.G. Seiler, Fischinger), Technische Universität München, München, Germany.
Abstract
PURPOSE: To determine the safety of superficial corneal crosslinking after laser in situ keratomileusis (LASIK). SETTING: Institut für Refraktive und Ophthalmo-Chirurgie, Zurich, Switzerland. DESIGN: Prospective study. METHODS: Eyes with an ectasia risk score of 2 or higher were treated with standard LASIK (90 μm flap) for myopia correction, after which a rapid corneal crosslinking was performed in the interface (riboflavin 0.5% for 2 minutes, 9 mW/cm(2) for 5 minutes) (Group 1). The follow-up was up to 1 year. The prevalence of complications was statistically compared with that in a group of eyes matched regarding age, sex, and attempted refractive correction that were treated with standard LASIK only (Group 2). RESULTS: One month postoperatively, 5 eyes in Group 1 lost 1 line of corrected distance visual acuity (CDVA) compared with 1 eye in Group 2 (P < .05). One year postoperatively, all eyes regained their preoperative CDVA, indicating a complication rate of less than 5%. The refractive success was identical in both groups. Early postoperative complications such as erosions (16%), diffuse lamellar keratitis (DLK) stage 1 (38%), and DLK stage 2 (5%) were statistically significantly more frequent after superficial corneal crosslinking, leading to a statistically significantly reduced uncorrected distance visual acuity at 1 month (P < .001). CONCLUSIONS: Based on 1-year results, superficial corneal crosslinking might be considered a safe adjunct to LASIK, with a delayed visual rehabilitation and a higher prevalence of transient side effects. It is not proved whether superficial corneal crosslinking can prevent iatrogenic keratectasia. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
PURPOSE: To determine the safety of superficial corneal crosslinking after laser in situ keratomileusis (LASIK). SETTING: Institut für Refraktive und Ophthalmo-Chirurgie, Zurich, Switzerland. DESIGN: Prospective study. METHODS: Eyes with an ectasia risk score of 2 or higher were treated with standard LASIK (90 μm flap) for myopia correction, after which a rapid corneal crosslinking was performed in the interface (riboflavin 0.5% for 2 minutes, 9 mW/cm(2) for 5 minutes) (Group 1). The follow-up was up to 1 year. The prevalence of complications was statistically compared with that in a group of eyes matched regarding age, sex, and attempted refractive correction that were treated with standard LASIK only (Group 2). RESULTS: One month postoperatively, 5 eyes in Group 1 lost 1 line of corrected distance visual acuity (CDVA) compared with 1 eye in Group 2 (P < .05). One year postoperatively, all eyes regained their preoperative CDVA, indicating a complication rate of less than 5%. The refractive success was identical in both groups. Early postoperative complications such as erosions (16%), diffuse lamellar keratitis (DLK) stage 1 (38%), and DLK stage 2 (5%) were statistically significantly more frequent after superficial corneal crosslinking, leading to a statistically significantly reduced uncorrected distance visual acuity at 1 month (P < .001). CONCLUSIONS: Based on 1-year results, superficial corneal crosslinking might be considered a safe adjunct to LASIK, with a delayed visual rehabilitation and a higher prevalence of transient side effects. It is not proved whether superficial corneal crosslinking can prevent iatrogenic keratectasia. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
Authors: Aris Konstantopoulos; Yu-Chi Liu; Ericia P Teo; Chan L Nyein; Gary H Yam; Jodhbir S Mehta Journal: Transl Vis Sci Technol Date: 2019-05-20 Impact factor: 3.283
Authors: Vardhaman P Kankariya; Ankita B Dube; Michael A Grentzelos; George A Kontadakis; Vasilios F Diakonis; Myrsini Petrelli; George D Kymionis Journal: Indian J Ophthalmol Date: 2020-12 Impact factor: 1.848