| Literature DB >> 26702988 |
A M Api1, D Belsito2, S Bhatia3, M Bruze4, P Calow5, M L Dagli6, W Dekant7, A D Fryer8, L Kromidas3, S La Cava3, J F Lalko3, A Lapczynski3, D C Liebler9, Y Miyachi10, V T Politano3, G Ritacco3, D Salvito3, T W Schultz11, J Shen3, I G Sipes12, B Wall3, D K Wilcox3.
Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable. Copyright ÂEntities:
Keywords: Developmental and reproductive toxicity; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity and photoallergenicity; Repeated dose; Skin sensitization
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Year: 2015 PMID： 26702988 DOI： 10.1016/j.fct.2015.12.010
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023