| Literature DB >> 26702830 |
Jan Prochazka1, Michaela Prochazkova1, Wen Du2, Frantisek Spoutil3, Jolana Tureckova3, Renee Hoch4, Tomomi Shimogori5, Radislav Sedlacek3, John L Rubenstein4, Torsten Wittmann6, Ophir D Klein7.
Abstract
The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell ablation, and confocal live imaging, we identified a migratory population of Fgf8-expressing epithelial cells in the embryonic mandible. These Fgf8-expressing progenitors furnish the epithelial cells required for tooth development, and the progenitor population migrates toward a Shh-expressing region in the mandible, where the tooth placode will initiate. Inhibition of Fgf and Shh signaling disrupted the oriented migration of cells, leading to a failure of tooth development. These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ.Entities:
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Year: 2015 PMID： 26702830 PMCID： PMC4710359 DOI： 10.1016/j.devcel.2015.11.025
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270