Literature DB >> 26702825

Sperm DNA Methylation: Not a Vehicle for Dietary Reprogramming of Offspring?

Emma Whitelaw1.   

Abstract

Reporting in Developmental Cell, Shea et al. (2015) show, using an inbred mouse strain, that "epivariation"-stochastic individual differences in DNA methylation-is a much greater contributor to the sperm methylome than is diet. They conclude that DNA methylation is not the mechanism underlying the dietary reprogramming of offspring phenotype.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID: 26702825     DOI: 10.1016/j.devcel.2015.12.005

Source DB:  PubMed          Journal:  Dev Cell        ISSN: 1534-5807            Impact factor:   12.270


  1 in total

1.  DNA methylation in mice is influenced by genetics as well as sex and life experience.

Authors:  Sara A Grimm; Takashi Shimbo; Motoki Takaku; James W Thomas; Scott Auerbach; Brian D Bennett; John R Bucher; Adam B Burkholder; Frank Day; Ying Du; Christopher G Duncan; John E French; Julie F Foley; Jianying Li; B Alex Merrick; Raymond R Tice; Tianyuan Wang; Xiaojiang Xu; Pierre R Bushel; David C Fargo; James C Mullikin; Paul A Wade
Journal:  Nat Commun       Date:  2019-01-18       Impact factor: 14.919

  1 in total

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