Gregory Amouyal1,2, Nicolas Thiounn3,4, Olivier Pellerin5,6,7, Lin Yen-Ting8, Costantino Del Giudice9,10, Carole Dean11,12, Helena Pereira13,14, Gilles Chatellier15,16, Marc Sapoval17,18,19. 1. Faculté de Médecine, Université Paris Descartes - Sorbonne - Paris - Cité, Paris, France. gregamouyal@hotmail.com. 2. Interventional Radiology Department, Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France. gregamouyal@hotmail.com. 3. Faculté de Médecine, Université Paris Descartes - Sorbonne - Paris - Cité, Paris, France. nicolas.thiounn@aphp.fr. 4. Urology Department, Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015, Paris, France. nicolas.thiounn@aphp.fr. 5. Faculté de Médecine, Université Paris Descartes - Sorbonne - Paris - Cité, Paris, France. olivier.pellerin@aphp.fr. 6. Interventional Radiology Department, Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France. olivier.pellerin@aphp.fr. 7. INSERM U970, Paris, France. olivier.pellerin@aphp.fr. 8. Interventional Radiology Department, Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France. ymerically@gmail.com. 9. Faculté de Médecine, Université Paris Descartes - Sorbonne - Paris - Cité, Paris, France. costantino.delgiudice@aphp.fr. 10. Interventional Radiology Department, Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France. costantino.delgiudice@aphp.fr. 11. Interventional Radiology Department, Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France. carole.dean@aphp.fr. 12. INSERM U970, Paris, France. carole.dean@aphp.fr. 13. Clinical Research Unit, Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France. helena.pereira@aphp.fr. 14. INSERM U1418, Paris, France. helena.pereira@aphp.fr. 15. Faculté de Médecine, Université Paris Descartes - Sorbonne - Paris - Cité, Paris, France. gilles.chatellier@aphp.fr. 16. INSERM U1418, Paris, France. gilles.chatellier@aphp.fr. 17. Faculté de Médecine, Université Paris Descartes - Sorbonne - Paris - Cité, Paris, France. marc.sapoval2@aphp.fr. 18. Interventional Radiology Department, Assistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France. marc.sapoval2@aphp.fr. 19. INSERM U970, Paris, France. marc.sapoval2@aphp.fr.
Abstract
BACKGROUND: Prostatic artery embolization (PAE) has been performed for a few years, but there is no report on PAE using the PErFecTED technique outside from the team that initiated this approach. OBJECTIVE: This single-center retrospective open label study reports our experience and clinical results on patients suffering from symptomatic BPH, who underwent PAE aiming at using the PErFecTED technique. MATERIALS AND METHODS: We treated 32 consecutive patients, mean age 65 (52-84 years old) between December 2013 and January 2015. Patients were referred for PAE after failure of medical treatment and refusal or contra-indication to surgery. They were treated using the PErFecTED technique, when feasible, with 300-500 µm calibrated microspheres (two-night hospital stay or outpatient procedure). Follow-up was performed at 3, 6, and 12 months. RESULTS: We had a 100% immediate technical success of embolization (68% of feasibility of the PErFecTED technique) with no immediate complications. After a mean follow-up of 7.7 months, we observed a 78% rate of clinical success. Mean IPSS decreased from 15.3 to 4.2 (p = .03), mean QoL from 5.4 to 2 (p = .03), mean Qmax increased from 9.2 to 19.2 (p = .25), mean prostatic volume decreased from 91 to 62 (p = .009) mL. There was no retrograde ejaculation and no major complication. CONCLUSION: PAE using the PErFecTED technique is a safe and efficient technique to treat bothersome LUTS related to BPH. It is of interest to note that the PErFecTED technique cannot be performed in some cases for anatomical reasons.
BACKGROUND:Prostatic artery embolization (PAE) has been performed for a few years, but there is no report on PAE using the PErFecTED technique outside from the team that initiated this approach. OBJECTIVE: This single-center retrospective open label study reports our experience and clinical results on patients suffering from symptomatic BPH, who underwent PAE aiming at using the PErFecTED technique. MATERIALS AND METHODS: We treated 32 consecutive patients, mean age 65 (52-84 years old) between December 2013 and January 2015. Patients were referred for PAE after failure of medical treatment and refusal or contra-indication to surgery. They were treated using the PErFecTED technique, when feasible, with 300-500 µm calibrated microspheres (two-night hospital stay or outpatient procedure). Follow-up was performed at 3, 6, and 12 months. RESULTS: We had a 100% immediate technical success of embolization (68% of feasibility of the PErFecTED technique) with no immediate complications. After a mean follow-up of 7.7 months, we observed a 78% rate of clinical success. Mean IPSS decreased from 15.3 to 4.2 (p = .03), mean QoL from 5.4 to 2 (p = .03), mean Qmax increased from 9.2 to 19.2 (p = .25), mean prostatic volume decreased from 91 to 62 (p = .009) mL. There was no retrograde ejaculation and no major complication. CONCLUSION: PAE using the PErFecTED technique is a safe and efficient technique to treat bothersome LUTS related to BPH. It is of interest to note that the PErFecTED technique cannot be performed in some cases for anatomical reasons.