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Literature DB >> 26702302

Recent advances and versatility of MAGE towards industrial applications.

Abstract

The genome engineering toolkit has expanded significantly in recent years, allowing us to study the functions of genes in cellular networks and assist in over-production of proteins, drugs, chemicals and biofuels. Multiplex automated genome engineering (MAGE) has been recently developed and gained more scientific interest towards strain engineering. MAGE is a simple, rapid and efficient tool for manipulating genes simultaneously in multiple loci, assigning genetic codes and integrating non-natural amino acids. MAGE can be further expanded towards the engineering of fast, robust and over-producing strains for chemicals, drugs and biofuels at industrial scales.

Keywords: Biofuels; Chemicals; Drugs; Genome; Multiplex automated genome engineering

Year: 2015 PMID： 26702302 PMCID： PMC4688408 DOI： 10.1007/s11693-015-9184-8

Source DB: PubMed Journal: Syst Synth Biol ISSN： 1872-5325

48 in total

1. Programmable single-cell mammalian biocomputers.

Authors: Simon Ausländer; David Ausländer; Marius Müller; Markus Wieland; Martin Fussenegger
Journal: Nature Date: 2012-07-05 Impact factor: 49.962

2. Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis.

Authors: Harris H Wang; Po-Yi Huang; George Xu; Wilhelm Haas; Adam Marblestone; Jun Li; Steven P Gygi; Anthony C Forster; Michael C Jewett; George M Church
Journal: ACS Synth Biol Date: 2012-02-17 Impact factor: 5.110

3. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems.

Authors: Yvonne Y Chen; Michael C Jensen; Christina D Smolke
Journal: Proc Natl Acad Sci U S A Date: 2010-04-26 Impact factor: 11.205

4. Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages.

Authors: Simanti Datta; Nina Costantino; Xiaomei Zhou; Donald L Court
Journal: Proc Natl Acad Sci U S A Date: 2008-01-29 Impact factor: 11.205

Review 1. Rewriting the Genetic Code.

Authors: Takahito Mukai; Marc J Lajoie; Markus Englert; Dieter Söll
Journal: Annu Rev Microbiol Date: 2017-07-11 Impact factor: 15.500

Review 2. Site-Specific Incorporation of Unnatural Amino Acids into Escherichia coli Recombinant Protein: Methodology Development and Recent Achievement.

Authors: Sviatlana Smolskaya; Yaroslav A Andreev
Journal: Biomolecules Date: 2019-06-28

2 in total

Recent advances and versatility of MAGE towards industrial applications.

1. Programmable single-cell mammalian biocomputers.

2. Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis.

3. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems.

4. Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages.

5. Programming cells by multiplex genome engineering and accelerated evolution.

6. Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection.

7. Recoded organisms engineered to depend on synthetic amino acids.

8. An engineered small RNA-mediated genetic switch based on a ribozyme expression platform.

9. A simple and effective method for construction of Escherichia coli strains proficient for genome engineering.

10. A fast, robust and tunable synthetic gene oscillator.

Review 1. Rewriting the Genetic Code.

Review 2. Site-Specific Incorporation of Unnatural Amino Acids into Escherichia coli Recombinant Protein: Methodology Development and Recent Achievement.