Lucas G Gimenez1,2, Hugo B Krupitzki1, Allison M Momany3, Juan A Gili1,2, Fernando A Poletta1,2,4, Hebe Campaña5, Viviana R Cosentino2, César Saleme6, Mariela Pawluk1,2, Jeffrey C Murray3, Eduardo E Castilla2,4, Enrique C Gadow1, Jorge S Lopez-Camelo1,2,4. 1. a Dirección De Investigación, CEMIC (Centro De Educación Médica E Investigaciones Clínicas) , Galván 4102 , Buenos Aires , Argentina . 2. b ECLAMC (Estudio Colaborativo Latinoamericano De Malformaciones Congénitas) at CEMIC , Buenos Aires , Argentina . 3. c Department of Pediatrics , University of Iowa , IA , USA . 4. d Fundação Oswaldo Cruz, INAGEMP (Instituto Nacional De Genética Médica Populacional) at Laboratório De Epidemiologia De Malformações Congênitas, Instituto Oswaldo Cruz , Rio De Janeiro , Brazil . 5. e CIC (Comisión De Investigaciones Científicas) at La Plata , Buenos Aires , Argentina , and. 6. f Maternidad Nuestra Señora De La Merced , Tucumán , Argentina.
Abstract
OBJECTIVE: This study was designed to characterize and compare the maternal and newborn epidemiological characteristics through analysis of environmental factors, sociodemographic characteristics and clinical characteristics between the different clinical subtypes of preterm birth (PTB): Idiopathic (PTB-I), premature rupture of the membranes (PTB-PPROM) and medically indicated (PTB-M). The two subtypes PTB-I and PTB-PPROM grouped are called spontaneous preterm births (PTB-S). METHODS: A retrospective, observational study was conducted in 1.291 preterm nonmalformed singleton live-born children to nulliparous and multiparous mother's in Tucumán-Argentina between 2005 and 2010. Over 50 maternal variables and 10 newborn variables were compared between the different clinical subtypes. The comparisons were done to identify heterogeneity between subtypes of preterm birth: (PTB-S) versus (PTB-M), and within spontaneous subtype: (PTB-I) versus (PTB-PPROM). In the same way, two conditional logistic multivariate regressions were used to compare the odds ratio (OR) between PTB-S and PTB-M, as well as PTB-I and PTB-PPROM. We matched for maternal age when comparing maternal variables and gestational age when comparing infant variables. RESULTS: The PTB-I subtype was characterized by younger mothers of lower socio-economic status, PTB-PPROM was characterized by environmental factors resulting from inflammatory processes, and PTB-M was characterized by increased maternal or fetal risk pregnancies. CONCLUSIONS: The main risk factor for PTB-I and PTB-M was having had a prior preterm delivery; however, previous spontaneous abortion was not a risk factor, suggesting a reproductive selection mechanism.
OBJECTIVE: This study was designed to characterize and compare the maternal and newborn epidemiological characteristics through analysis of environmental factors, sociodemographic characteristics and clinical characteristics between the different clinical subtypes of preterm birth (PTB): Idiopathic (PTB-I), premature rupture of the membranes (PTB-PPROM) and medically indicated (PTB-M). The two subtypes PTB-I and PTB-PPROM grouped are called spontaneous preterm births (PTB-S). METHODS: A retrospective, observational study was conducted in 1.291 preterm nonmalformed singleton live-born children to nulliparous and multiparous mother's in Tucumán-Argentina between 2005 and 2010. Over 50 maternal variables and 10 newborn variables were compared between the different clinical subtypes. The comparisons were done to identify heterogeneity between subtypes of preterm birth: (PTB-S) versus (PTB-M), and within spontaneous subtype: (PTB-I) versus (PTB-PPROM). In the same way, two conditional logistic multivariate regressions were used to compare the odds ratio (OR) between PTB-S and PTB-M, as well as PTB-I and PTB-PPROM. We matched for maternal age when comparing maternal variables and gestational age when comparing infant variables. RESULTS: The PTB-I subtype was characterized by younger mothers of lower socio-economic status, PTB-PPROM was characterized by environmental factors resulting from inflammatory processes, and PTB-M was characterized by increased maternal or fetal risk pregnancies. CONCLUSIONS: The main risk factor for PTB-I and PTB-M was having had a prior preterm delivery; however, previous spontaneous abortion was not a risk factor, suggesting a reproductive selection mechanism.
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Authors: Dario E Elias; Maria R Santos; Hebe Campaña; Fernando A Poletta; Silvina L Heisecke; Juan A Gili; Julia Ratowiecki; Viviana Cosentino; Rocio Uranga; Diana Rojas Málaga; Alice Brinckmann Oliveira Netto; Ana Carolina Brusius-Facchin; César Saleme; Mónica Rittler; Hugo B Krupitzki; Jorge S Lopez Camelo; Lucas G Gimenez Journal: J Community Genet Date: 2022-08-17
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Authors: Lucas G Gimenez; Allison M Momany; Fernando A Poletta; Hugo B Krupitzki; Juan A Gili; Tamara D Busch; Cesar Saleme; Viviana R Cosentino; Mariela S Pawluk; Hebe Campaña; Enrique C Gadow; Jeffrey C Murray; Jorge S Lopez-Camelo Journal: Pediatr Res Date: 2017-05-31 Impact factor: 3.756
Authors: Dario Elias; Hebe Campaña; Fernando A Poletta; Silvina L Heisecke; Juan A Gili; Julia Ratowiecki; Mariela Pawluk; Maria R Santos; Viviana Cosentino; Rocio Uranga; Cesar Saleme; Monica Rittler; Hugo B Krupitzki; Jorge S Lopez Camelo; Lucas G Gimenez Journal: Pediatr Res Date: 2021-07-19 Impact factor: 3.953