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Literature DB >> 26700912

Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?

Giuseppina Stifano¹, Romy Beatriz Christmann².

Abstract

The pathogenesis of systemic sclerosis is still unknown, although immune cells, mainly macrophages/monocytes, may have an important role in initiating and/or perpetuating the disease. Macrophages and monocytes are often classified as pro-inflammatory M1 phenotype or classic activation and pro-fibrotic/anti-inflammatory M2 phenotype or alternative activation. In this review, we highlighted the most relevant research regarding the involvement of macrophages/monocytes in the pathogenesis of this complex disease.

Entities: Disease

Keywords: Fibrosis; Macrophages; Monocytes; Pathogenesis; Scleroderma; Systemic sclerosis

Mesh：

Year: 2016 PMID： 26700912 DOI： 10.1007/s11926-015-0554-8

Source DB: PubMed Journal: Curr Rheumatol Rep ISSN： 1523-3774 Impact factor: 4.592

49 in total

1. Expression of RANTES in biopsies of skin and upper gastrointestinal tract from patients with systemic sclerosis.

Authors: O Distler; B Rinkes; U Hohenleutner; J Schölmerich; M Landthaler; B Lang; S Gay; U Müller-Ladner
Journal: Rheumatol Int Date: 1999 Impact factor: 2.631

2. CXCL10 (alpha) and CCL2 (beta) chemokines in systemic sclerosis--a longitudinal study.

Authors: A Antonelli; C Ferri; P Fallahi; S M Ferrari; D Giuggioli; M Colaci; A Manfredi; S Frascerra; F Franzoni; F Galetta; E Ferrannini
Journal: Rheumatology (Oxford) Date: 2008-01 Impact factor: 7.580

3. Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis.

Authors: O Distler; T Pap; O Kowal-Bielecka; R Meyringer; S Guiducci; M Landthaler; J Schölmerich; B A Michel; R E Gay; M Matucci-Cerinic; S Gay; U Müller-Ladner
Journal: Arthritis Rheum Date: 2001-11

4. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.

Authors: K Hieshima; T Imai; M Baba; K Shoudai; K Ishizuka; T Nakagawa; J Tsuruta; M Takeya; Y Sakaki; K Takatsuki; R Miura; G Opdenakker; J Van Damme; O Yoshie; H Nomiyama
Journal: J Immunol Date: 1997-08-01 Impact factor: 5.422

5. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype.

Authors: Susan K Mathai; Mridu Gulati; Xueyan Peng; Thomas R Russell; Albert C Shaw; Ami N Rubinowitz; Lynne A Murray; Jonathan M Siner; Danielle E Antin-Ozerkis; Ruth R Montgomery; Ronald A S Reilkoff; Richard J Bucala; Erica L Herzog
Journal: Lab Invest Date: 2010-04-19 Impact factor: 5.662

6. Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and the type 1 tight-skin mouse.

Authors: Voon H Ong; Lowri A Evans; Xu Shiwen; Ivan B Fisher; Vineeth Rajkumar; David J Abraham; Carol M Black; Christopher P Denton
Journal: Arthritis Rheum Date: 2003-07

7. Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis.

Authors: Nobuyo Higashi-Kuwata; Masatoshi Jinnin; Takamitsu Makino; Satoshi Fukushima; Yuji Inoue; Faith C Muchemwa; Yuji Yonemura; Yoshihiro Komohara; Motohiro Takeya; Hiroaki Mitsuya; Hironobu Ihn
Journal: Arthritis Res Ther Date: 2010-07-05 Impact factor: 5.156

8. Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma.

Authors: Hangjun Duan; Jo Fleming; David K Pritchard; Lynn M Amon; Jun Xue; Heather A Arnett; Guang Chen; Patricia Breen; Jane H Buckner; Jerry A Molitor; Keith B Elkon; Stephen M Schwartz
Journal: Arthritis Rheum Date: 2008-05

9. High serum sCD163/sTWEAK ratio is associated with lower risk of digital ulcers but more severe skin disease in patients with systemic sclerosis.

Authors: Otylia Kowal-Bielecka; Marek Bielecki; Serena Guiducci; Beata Trzcinska-Butkiewicz; Małgorzata Michalska-Jakubus; Marco Matucci-Cerinic; Marek Brzosko; Dorota Krasowska; Lech Chyczewski; Krzysztof Kowal
Journal: Arthritis Res Ther Date: 2013 Impact factor: 5.156

Review 10. The M1 and M2 paradigm of macrophage activation: time for reassessment.

Authors: Fernando O Martinez; Siamon Gordon
Journal: F1000Prime Rep Date: 2014-03-03

30 in total

Review 1. Myeloid Populations in Systemic Autoimmune Diseases.

Authors: María Morell; Nieves Varela; Concepción Marañón
Journal: Clin Rev Allergy Immunol Date: 2017-10 Impact factor: 8.667

2. RGC32 Promotes Bleomycin-Induced Systemic Sclerosis in a Murine Disease Model by Modulating Classically Activated Macrophage Function.

Authors: Chenming Sun; Shi-You Chen
Journal: J Immunol Date: 2018-03-05 Impact factor: 5.422

3. Fos-related antigen-1 transgenic mouse as a model for systemic sclerosis: A potential role of M2 polarization.

Authors: Hidekata Yasuoka; Yuen Yu Angela Tam; Yuka Okazaki; Yuichi Tamura; Koichi Matsuo; Carol Feghali-Bostwick; Tsutomu Takeuchi; Masataka Kuwana
Journal: J Scleroderma Relat Disord Date: 2019-05-19

Review 4. Rationale for the evaluation of nintedanib as a treatment for systemic sclerosis-associated interstitial lung disease.

Authors: Lutz Wollin; Jörg Hw Distler; Christopher P Denton; Martina Gahlemann
Journal: J Scleroderma Relat Disord Date: 2019-04-21

Review 5. Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis.

Authors: Gabriela Kania; Michal Rudnik; Oliver Distler
Journal: Nat Rev Rheumatol Date: 2019-05 Impact factor: 20.543

6. Flow cytometry evaluation of CD14/CD16 monocyte subpopulations in systemic sclerosis patients: a cross sectional controlled study.

Authors: Laiana Schneider; Natália Aydos Marcondes; Vanessa Hax; Isadora Flesch da Silva Moreira; Carolina Yuka Ueda; Rafaella Romeiro Piovesan; Ricardo Xavier; Rafael Chakr
Journal: Adv Rheumatol Date: 2021-05-22

7. VISTA is an activating receptor in human monocytes.

Authors: Bryan M Rogers; Laura Smith; Zoltan Dezso; Xu Shi; Enrico DiGiammarino; Denny Nguyen; Sunantha Sethuraman; Pingping Zheng; Donghee Choi; Dong Zhang; Andrew Nguyen; Kathleen McGuire; Wei Liu; Namjin Chung; Debra T Chao; Shiming Ye; Gabriel R Starbeck-Miller
Journal: J Exp Med Date: 2021-06-09 Impact factor: 14.307

Review 8. New promising drugs for the treatment of systemic sclerosis: pathogenic considerations, enhanced classifications, and personalized medicine.

Authors: Alain Lescoat; John Varga; Marco Matucci-Cerinic; Dinesh Khanna
Journal: Expert Opin Investig Drugs Date: 2021-05-13 Impact factor: 6.498

9. Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure.

Authors: Lingwen Ying; Mingliang Zhang; Xiaojing Ma; Yiming Si; Xiaoya Li; Jiaorong Su; Jun Yin; Yuqian Bao
Journal: Front Cell Dev Biol Date: 2021-05-20

10. Identification of Potential ceRNA Network and Patterns of Immune Cell Infiltration in Systemic Sclerosis-Associated Interstitial Lung Disease.

Authors: Qiuhong Wu; Yang Liu; Yan Xie; Shixiong Wei; Yi Liu
Journal: Front Cell Dev Biol Date: 2021-06-17