William J Mackillop1, Weidong Kong2. 1. Cancer Care and Epidemiology, Queen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada; Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada; Department of Oncology, Queen's University, Kingston, Ontario, Canada. Electronic address: william.mackillop@krcc.on.ca. 2. Cancer Care and Epidemiology, Queen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada.
Abstract
PURPOSE: Palliative radiation therapy (PRT) benefits many patients with incurable cancer, but the overall need for PRT is unknown. Our primary objective was to estimate the appropriate rate of use of PRT in Ontario. METHODS AND MATERIALS: The Ontario Cancer Registry identified patients who died of cancer in Ontario between 2006 and 2010. Comprehensive RT records were linked to the registry. Multivariate analysis identified social and health system-related factors affecting the use of PRT, enabling us to define a benchmark population of patients with unimpeded access to PRT. The proportion of cases treated at any time (PRTlifetime), the proportion of cases treated in the last 2 years of life (PRT2y), and number of courses of PRT per thousand cancer deaths were measured in the benchmark population. These benchmarks were standardized to the characteristics of the overall population, and province-wide PRT rates were then compared to benchmarks. RESULTS: Cases diagnosed at hospitals with no RT on-site and residents of poorer communities and those who lived farther from an RT center, were significantly less likely than others to receive PRT. However, availability of RT at the diagnosing hospital was the dominant factor. Neither socioeconomic status nor distance from home to nearest RT center had a significant effect on the use of PRT in patients diagnosed at a hospital with RT facilities. The benchmark population therefore consisted of patients diagnosed at a hospital with RT facilities. The standardized benchmark for PRTlifetime was 33.9%, and the corresponding province-wide rate was 28.5%. The standardized benchmark for PRT2y was 32.4%, and the corresponding province-wide rate was 27.0%. The standardized benchmark for the number of courses of PRT per thousand cancer deaths was 652, and the corresponding province-wide rate was 542. CONCLUSIONS: Approximately one-third of patients who die of cancer in Ontario need PRT, but many of them are never treated.
PURPOSE: Palliative radiation therapy (PRT) benefits many patients with incurable cancer, but the overall need for PRT is unknown. Our primary objective was to estimate the appropriate rate of use of PRT in Ontario. METHODS AND MATERIALS: The Ontario Cancer Registry identified patients who died of cancer in Ontario between 2006 and 2010. Comprehensive RT records were linked to the registry. Multivariate analysis identified social and health system-related factors affecting the use of PRT, enabling us to define a benchmark population of patients with unimpeded access to PRT. The proportion of cases treated at any time (PRTlifetime), the proportion of cases treated in the last 2 years of life (PRT2y), and number of courses of PRT per thousand cancer deaths were measured in the benchmark population. These benchmarks were standardized to the characteristics of the overall population, and province-wide PRT rates were then compared to benchmarks. RESULTS: Cases diagnosed at hospitals with no RT on-site and residents of poorer communities and those who lived farther from an RT center, were significantly less likely than others to receive PRT. However, availability of RT at the diagnosing hospital was the dominant factor. Neither socioeconomic status nor distance from home to nearest RT center had a significant effect on the use of PRT in patients diagnosed at a hospital with RT facilities. The benchmark population therefore consisted of patients diagnosed at a hospital with RT facilities. The standardized benchmark for PRTlifetime was 33.9%, and the corresponding province-wide rate was 28.5%. The standardized benchmark for PRT2y was 32.4%, and the corresponding province-wide rate was 27.0%. The standardized benchmark for the number of courses of PRT per thousand cancer deaths was 652, and the corresponding province-wide rate was 542. CONCLUSIONS: Approximately one-third of patients who die of cancer in Ontario need PRT, but many of them are never treated.
Authors: Safiya Karim; William J Mackillop; Kelly Brennan; Yingwei Peng; D Robert Siemens; Monika K Krzyzanowska; Christopher M Booth Journal: Cancer Med Date: 2019-08-31 Impact factor: 4.452
Authors: Yunfei Hu; Mikel Byrne; Ben Archibald-Heeren; Matthew Squires; Amy Teh; Kylie Seiffert; Sonja Cheers; Yang Wang Journal: J Med Phys Date: 2017 Jul-Sep