| Literature DB >> 26700398 |
Zhi-Jun Zhang1,2, Ru-Nan Du2, Juan He2, Xing-De Wu2, Yan Li2, Rong-Tao Li1, Qin-Shi Zhao2.
Abstract
Three new monoterpenoid indole alkaloids, 19-hydroxyl-10-methoxy-19, 20-dihydrovinorine (1), 19-O-acetyl-10-methoxy-19, 20-dihydrovinorine (2), and 19, 21α-dihydroxyl-10-methoxy-19, 20-dihydrovinorine (3), along with five known analogues (4-8), were isolated from the whole plants of Vinca major. The new structures were elucidated by extensive NMR and MS analysis and comparison with known compounds. In addition, compounds 1-3 were evaluated for their cytotoxicities against five human cancer cell lines.Entities:
Keywords: Apocynaceae; Vinca major; cytotoxicity; monoterpenoid indole alkaloid
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Year: 2015 PMID： 26700398 DOI： 10.1080/10286020.2015.1094463
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569