Zhi-Xiong Li1, Xiao-Hua Wu2, Hai-yan Wu3, Wen-Ju Chang4, Xiu-juan Chang5, Tuo Yi4, Qiang Shi6, Jing-Wen Chen4, Qing-Yang Feng4, De-Xiang Zhu4, Ye Wei7, Yun-Shi Zhong8, Jian-Min Xu4. 1. Department of Gastrointestinal Surgery, The First Hospital of Putian, Fu Jian, 351100, China. 2. Department of General Surgery, The First Hospital of Nan Ping, Fu Jian, 353000, China. 3. Department of Pathology, The First Hospital of Putian, Fu Jian, 351100, China. 4. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. 5. Center for Therapeutic Research of Hepatocarcinoma, Beijing 302 Hospital, Beijing, 100000, China. 6. Department of Endoscopic Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. 7. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. wei.ye@zs-hospital.sh.cn. 8. Department of Endoscopic Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. zhong.yunshi@zs-hospital.sh.cn.
Abstract
BACKGROUD: The efficacy and safety of self-expandable metallic stents (SEMSs) as a bridge for patients with acute malignant colorectal obstructions (AMCOs) are still controversial. We conducted this study to evaluate the outcomes of patients with AMCOs treated by different strategies. METHODS: From January 2010 to March 2014, a total of 171 patients with AMCOs from Zhongshan Hospital were retrospectively enrolled in this study. One hundred twenty patients successfully received stent placement followed by one-stage laparoscopic or open resection in the stent group, and 51 patients received emergency operations in the emergency group. RESULTS: The operation duration and postoperative hospital stay were significantly shorter in the stent group (114.51 ± 28.65 vs. 160.39 ± 58.94 min, P < 0.001; 8.00 ± 3.97 vs. 12.59 ± 9.07 days, P = 0.001). The stent group also had significantly reduced intraoperative blood loss and the incidence of postoperative complications compared with the emergency group (61.00 ± 43.70 vs. 121.18 ± 85.90 ml, P < 0.001; 16.7 vs. 37.3%, P = 0.003). Kaplan-Meier survival curves showed that the median survival time in the stent group was significantly longer than that in the emergency group (53 vs. 41 months, P = 0.034). In subgroup analysis of stent group, the stent laparoscopy group had significantly decreased postoperative complications (P = 0.025), and similar long-term survival (P = 0.81). CONCLUSIONS: Stent placement as a bridge to surgery is a safe and feasible procedure and provides significant advantages in terms of short-term outcomes and favorable prognoses for patients with AMCOs. Laparoscopic surgery could be considered as an optimal treatment after stent placement.
BACKGROUD: The efficacy and safety of self-expandable metallic stents (SEMSs) as a bridge for patients with acute malignant colorectal obstructions (AMCOs) are still controversial. We conducted this study to evaluate the outcomes of patients with AMCOs treated by different strategies. METHODS: From January 2010 to March 2014, a total of 171 patients with AMCOs from Zhongshan Hospital were retrospectively enrolled in this study. One hundred twenty patients successfully received stent placement followed by one-stage laparoscopic or open resection in the stent group, and 51 patients received emergency operations in the emergency group. RESULTS: The operation duration and postoperative hospital stay were significantly shorter in the stent group (114.51 ± 28.65 vs. 160.39 ± 58.94 min, P < 0.001; 8.00 ± 3.97 vs. 12.59 ± 9.07 days, P = 0.001). The stent group also had significantly reduced intraoperative blood loss and the incidence of postoperative complications compared with the emergency group (61.00 ± 43.70 vs. 121.18 ± 85.90 ml, P < 0.001; 16.7 vs. 37.3%, P = 0.003). Kaplan-Meier survival curves showed that the median survival time in the stent group was significantly longer than that in the emergency group (53 vs. 41 months, P = 0.034). In subgroup analysis of stent group, the stent laparoscopy group had significantly decreased postoperative complications (P = 0.025), and similar long-term survival (P = 0.81). CONCLUSIONS: Stent placement as a bridge to surgery is a safe and feasible procedure and provides significant advantages in terms of short-term outcomes and favorable prognoses for patients with AMCOs. Laparoscopic surgery could be considered as an optimal treatment after stent placement.
Entities:
Keywords:
Colorectal cancer; Endoscopy; Intestinal obstruction; Prognosis; Self-expandable metal stent; Surgery
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