Literature DB >> 26699787

Multiple amino acid substitutions involved in the adaptation of avian-origin influenza A (H10N7) virus in mice.

Haibo Wu1, Xiuming Peng1, Xiaorong Peng1, Linfang Cheng1, Changzhong Jin1, Xiangyun Lu1, Tiansheng Xie1, Hangping Yao1, Nanping Wu2.   

Abstract

To identify substitutions that are possibly associated with the adaptation of avian-origin H10N7 virus to mammals, adaptation of the H10N7 virus in mouse lung was carried out by serial lung-to-lung passage. Genomic analysis of the mouse-adapted virus revealed amino acid changes in the PB2 (E627K), PA (T97I), and HA (G409E) proteins, and this virus was more virulent in mice than the wild-type virus. Our results suggest that these substitutions are involved in the enhancement of the replication efficiency of avian-origin H10N7 virus, resulting in severe disease in mice. Continued poultry surveillance of these substitutions in H10N7 viruses is required.

Entities:  

Keywords:  Adaptation; Avian influenza viruses; Mice; Replication; Subtype H10N7; Virulence

Mesh：

Substances：

Year:  2015        PMID： 26699787     DOI： 10.1007/s00705-015-2722-6

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  8 in total

1.  Multiple amino acid substitutions involved in the adaption of three avian-origin H7N9 influenza viruses in mice.

Authors:  Jianru Qin; Ouyang Peng; Xiaoting Shen; Lang Gong; Chunyi Xue; Yongchang Cao
Journal:  Virol J       Date:  2019-01-08       Impact factor: 4.099

2.  Rapid acquisition of polymorphic virulence markers during adaptation of highly pathogenic avian influenza H5N8 virus in the mouse.

Authors:  Won-Suk Choi; Yun Hee Baek; Jin Jung Kwon; Ju Hwan Jeong; Su-Jin Park; Young-Il Kim; Sun-Woo Yoon; Jungwon Hwang; Myung Hee Kim; Chul-Joong Kim; Richard J Webby; Young Ki Choi; Min-Suk Song
Journal:  Sci Rep       Date:  2017-01-17       Impact factor: 4.379

Review 3.  The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents.

Authors:  Won-Suk Choi; Khristine Kaith S Lloren; Yun Hee Baek; Min-Suk Song
Journal:  Clin Exp Vaccine Res       Date:  2017-07-26

4.  Human surveillance and phylogeny of highly pathogenic avian influenza A(H5N8) during an outbreak in poultry in South Africa, 2017.

Authors:  Ziyaad Valley-Omar; Alicia Cloete; Reneé Pieterse; Sibongile Walaza; Yusrah Salie-Bassier; Mikhail Smith; Nevashan Govender; Mpho Seleka; Orienka Hellferscee; Phillip Senzo Mtshali; Mushal Allam; Arshad Ismail; Tasneem Anthony; Michelle Seutloali; Kerrigan McCarthy; Lesley van Helden; Cheryl Cohen; Florette Kathleen Treurnicht
Journal:  Influenza Other Respir Viruses       Date:  2020-02-14       Impact factor: 4.380

5.  Genetic Characterization and Pathogenesis of Three Novel Reassortant H5N2 Viruses in South Korea, 2018.

Authors:  Anh Thi Viet Nguyen; Vui Thi Hoang; Haan Woo Sung; Seon-Ju Yeo; Hyun Park
Journal:  Viruses       Date:  2021-10-30       Impact factor: 5.048

6.  Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks.

Authors:  Miaomiao Zhang; Xingxing Zhang; Kaidi Xu; Qiaoyang Teng; Qinfang Liu; Xuesong Li; Jianmei Yang; Jianqing Xu; Hongjun Chen; Xiaoyan Zhang; Zejun Li
Journal:  Sci Rep       Date:  2016-09-28       Impact factor: 4.379

7.  Amino Acid Substitutions Associated with Avian H5N6 Influenza A Virus Adaptation to Mice.

Authors:  Chunmao Zhang; Zongzheng Zhao; Zhendong Guo; Jiajie Zhang; Jiaming Li; Yifei Yang; Shaoxia Lu; Zhongyi Wang; Min Zhi; Yingying Fu; Xiaoyu Yang; Lina Liu; Yi Zhang; Yuping Hua; Linna Liu; Hongliang Chai; Jun Qian
Journal:  Front Microbiol       Date:  2017-09-15       Impact factor: 5.640

8.  Genetic characterization of H9N2 avian influenza viruses isolated from poultry in Poland during 2013/2014.

Authors:  Edyta Świętoń; Michał Jóźwiak; Zenon Minta; Krzysztof Śmietanka
Journal:  Virus Genes       Date:  2017-10-19       Impact factor: 2.332
  8 in total

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