Shin Ishihara1, Akihiko Horiguchi2, Shuichi Miyakawa3, Itaru Endo4, Masaru Miyazaki5, Tadahiro Takada6. 1. Department of General Surgery and Pancreatic Surgery, Fujita Health University, 1-98 Dengakygakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. 2. Department of General Surgery and Pancreatic Surgery, Fujita Health University, 1-98 Dengakygakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. akihori@fujita-hu.ac.jp. 3. Toyota Regional Medical Center, Toyota, Japan. 4. Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan. 5. Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan. 6. Department of Surgery, Teikyo University, Tokyo, Japan.
Abstract
BACKGROUND: The present study analyzed biliary tract cancer patients registered from 2008 to 2013 in Japan and evaluated the outcomes of biliary tract cancer. METHODS: A total of 18,606 patients were registered from 2008 to 2013. Cases were analyzed with regard to patient survival according to contiguous extent of the primary tumor (T), node metastasis, and tumor stage using the 3rd English edition of the Japanese classification of the biliary tract cancers. RESULTS: Five-year survival rates were 39.8% for gallbladder cancer, 24.2% for perihilar bile duct cancer, 39.1% for distal bile duct cancer, and 61.3% for ampullary region cancer. Significant differences were observed between newly introduced subdivisions in the new Japanese classification for all tumoral sites except gallbladder cancer. The survival rate in patients with #13a metastasis was significantly higher than in patients with distant lymph node metastasis. CONCLUSIONS: The new Japanese classification adopted the 7th edition of staging system developed by the Union for International Cancer Control staging system. However, numerous aspects of these classification systems remain unvalidated. The present analysis demonstrated the significance of a proportion of T factor subdivisions and classifications of regional lymph nodes in cases of gallbladder cancer in the new Japanese classification.
BACKGROUND: The present study analyzed biliary tract cancerpatients registered from 2008 to 2013 in Japan and evaluated the outcomes of biliary tract cancer. METHODS: A total of 18,606 patients were registered from 2008 to 2013. Cases were analyzed with regard to patient survival according to contiguous extent of the primary tumor (T), node metastasis, and tumor stage using the 3rd English edition of the Japanese classification of the biliary tract cancers. RESULTS: Five-year survival rates were 39.8% for gallbladder cancer, 24.2% for perihilar bile duct cancer, 39.1% for distal bile duct cancer, and 61.3% for ampullary region cancer. Significant differences were observed between newly introduced subdivisions in the new Japanese classification for all tumoral sites except gallbladder cancer. The survival rate in patients with #13a metastasis was significantly higher than in patients with distant lymph node metastasis. CONCLUSIONS: The new Japanese classification adopted the 7th edition of staging system developed by the Union for International Cancer Control staging system. However, numerous aspects of these classification systems remain unvalidated. The present analysis demonstrated the significance of a proportion of T factor subdivisions and classifications of regional lymph nodes in cases of gallbladder cancer in the new Japanese classification.
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