Dong Qian1, Zipeng Lu1, Richard Jackson2, Junli Wu1, Xinchun Liu1, Baobao Cai1, Pengfei Wu1, Jie Yin1, Qingcheng Xu1, Dong Xu1, Yunpeng Peng1, Kuirong Jiang3, Yi Miao4. 1. Pancreas Center, Department of General Surgery, the First Affiliated Hospital With Nanjing Medical University, Nanjing, China. 2. Cancer Research UK Liverpool Cancer Trials Unit, University of Liverpool, UK. 3. Pancreas Center, Department of General Surgery, the First Affiliated Hospital With Nanjing Medical University, Nanjing, China. Electronic address: jiangkuirong@njmu.edu.cn. 4. Pancreas Center, Department of General Surgery, the First Affiliated Hospital With Nanjing Medical University, Nanjing, China. Electronic address: miaoyi@njmu.edu.cn.
Abstract
BACKGROUND: Delayed gastric emptying (DGE) is one of the most troublesome complications after classical pancreaticoduodenectomy (PD) or pylorus-preserving PD. Whether the route of gastroenteric reconstruction has any influence on DGE remains controversial. The aim of this study was to investigate the influence of different types of gastroenteric anastomosis on DGE after PD/PPPD. METHODS: A systematic search of literature databases (Cochrane Library, PubMed, EMBASE, and Web of Science) was performed to identify eligible studies. Cochrane collaboration's tool for assessing risk of bias was utilized to evaluate the quality of included studies. The primary outcome was DGE incidence rate. Further outcomes included mortality, morbidity, and other operation related events. Random-effect or fix-effect models were used as appropriate. RESULTS: Five randomized controlled trials (RCTs) including a total of 530 patients were identified and included in the analysis. Based on these studies, no difference was found in DGE incidence between antecolic and retrocolic groups (relative risk [RR], 0.82; 95% confidence interval [CI], 0.51-1.32; P = 0.41). Mortality, morbidity, and operation related events were not significantly different between groups. CONCLUSIONS: Results of the meta-analysis reveal that DGE occurrence is not affected by route of gastroenteric anastomosis. Anastomosis approach should be chosen according to the surgeons' preference.
BACKGROUND: Delayed gastric emptying (DGE) is one of the most troublesome complications after classical pancreaticoduodenectomy (PD) or pylorus-preserving PD. Whether the route of gastroenteric reconstruction has any influence on DGE remains controversial. The aim of this study was to investigate the influence of different types of gastroenteric anastomosis on DGE after PD/PPPD. METHODS: A systematic search of literature databases (Cochrane Library, PubMed, EMBASE, and Web of Science) was performed to identify eligible studies. Cochrane collaboration's tool for assessing risk of bias was utilized to evaluate the quality of included studies. The primary outcome was DGE incidence rate. Further outcomes included mortality, morbidity, and other operation related events. Random-effect or fix-effect models were used as appropriate. RESULTS: Five randomized controlled trials (RCTs) including a total of 530 patients were identified and included in the analysis. Based on these studies, no difference was found in DGE incidence between antecolic and retrocolic groups (relative risk [RR], 0.82; 95% confidence interval [CI], 0.51-1.32; P = 0.41). Mortality, morbidity, and operation related events were not significantly different between groups. CONCLUSIONS: Results of the meta-analysis reveal that DGE occurrence is not affected by route of gastroenteric anastomosis. Anastomosis approach should be chosen according to the surgeons' preference.
Authors: Felix J Hüttner; Rosa Klotz; Alexis Ulrich; Markus W Büchler; Pascal Probst; Markus K Diener Journal: Cochrane Database Syst Rev Date: 2022-01-11
Authors: Matthias C Schrempf; David R M Pinto; Sebastian Wolf; Bernd Geissler; Florian Sommer; Michael Hoffmann; Dmytro Vlasenko; Johanna Gutschon; Matthias Anthuber Journal: Trials Date: 2022-01-25 Impact factor: 2.279