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Literature DB >> 26699640

Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.

Bishal Kumar Singh¹, Anna Koromyslova¹, Lisa Hefele¹, Clara Gürth¹, Grant S Hansman².

Abstract

Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.

Entities: Species

Mesh：

Substances：
Antibodies, Viral

Year: 2015 PMID： 26699640 PMCID： PMC4810701 DOI： 10.1128/JVI.03119-15

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

32 in total

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2. Atomic Structure of the Murine Norovirus Protruding Domain and Soluble CD300lf Receptor Complex.

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3. Human Norovirus Neutralized by a Monoclonal Antibody Targeting the Histo-Blood Group Antigen Pocket.

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4. Structural Basis for Human Norovirus Capsid Binding to Bile Acids.

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