Jian Li1,2, Guifen Niu2, Huaiguo Wang3, Kun Wang2, Bingtong Huang2, Minglong Li1. 1. a Department of Endocrinology , Shandong Provincial Hospital Affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine , 324 Jing 5 Rd , Jinan , Shandong , P.R. China . 2. b Department of Endocrinology , Liaocheng People's Hospital , 67 Dongchang Xi Rd , Liaocheng , Shandong , P.R. China , and. 3. c Department of Nephrology , Liaocheng People's Hospital , 67 Dongchang Xi Rd , Liaocheng , Shandong , P.R. China.
Abstract
OBJECTIVE: Serum YKL-40 levels are elevated in patients with type 1 and 2 diabetes. However, the correlation between YKL-40 and gestational diabetes mellitus (GDM) remains unknown. The present study compared serum YKL-40 levels in pregnant women with GDM and those with normal glucose tolerance and evaluated the relationship between YKL-40 and insulin-resistant syndrome. METHODS: Thirty-five patients with GDM and 43 age-matched healthy pregnant women at 24-28 weeks of gestation were studied. In addition to anthropometric assessments, serum glucose, insulin, YKL-40, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein and glycated hemoglobin were measured in all subjects. All subjects underwent a 2-h 75-g oral glucose tolerance test (OGTT). Body mass index (BMI) and the homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. RESULTS: Fasting and 2 h serum YKL-40 levels were significantly higher in pregnant women with GDM compared with controls (77.3 ± 29.3 versus 50.9 ± 16.7 ng/mL, p < 0.001, fasting concentrations; 63.5 ± 20.1 versus 40.6 ± 10.7 ng/mL, p = 0.009, 2 h concentrations). OGTT had no effect on YKL-40 levels in either group (p > 0.05). There were significant correlations between YKL-40 and glycated hemoglobin (β = 0.37, p = 0.006), fasting insulin (β = 0.49, p = 0.001) and HOMA-IR (β = 0.18, p = 0.015) in the GDM group. CONCLUSIONS: Serum YKL-40 levels are elevated in patients with GDM but are unaffected by OGTT. YKL-40 levels are related to glycated hemoglobin, fasting insulin and HOMA-IR. These results suggest that YKL-40 may be a major contributor to GDM.
OBJECTIVE: Serum YKL-40 levels are elevated in patients with type 1 and 2 diabetes. However, the correlation between YKL-40 and gestational diabetes mellitus (GDM) remains unknown. The present study compared serum YKL-40 levels in pregnant women with GDM and those with normal glucose tolerance and evaluated the relationship between YKL-40 and insulin-resistant syndrome. METHODS: Thirty-five patients with GDM and 43 age-matched healthy pregnant women at 24-28 weeks of gestation were studied. In addition to anthropometric assessments, serum glucose, insulin, YKL-40, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein and glycated hemoglobin were measured in all subjects. All subjects underwent a 2-h 75-g oral glucose tolerance test (OGTT). Body mass index (BMI) and the homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. RESULTS: Fasting and 2 h serum YKL-40 levels were significantly higher in pregnant women with GDM compared with controls (77.3 ± 29.3 versus 50.9 ± 16.7 ng/mL, p < 0.001, fasting concentrations; 63.5 ± 20.1 versus 40.6 ± 10.7 ng/mL, p = 0.009, 2 h concentrations). OGTT had no effect on YKL-40 levels in either group (p > 0.05). There were significant correlations between YKL-40 and glycated hemoglobin (β = 0.37, p = 0.006), fasting insulin (β = 0.49, p = 0.001) and HOMA-IR (β = 0.18, p = 0.015) in the GDM group. CONCLUSIONS: Serum YKL-40 levels are elevated in patients with GDM but are unaffected by OGTT. YKL-40 levels are related to glycated hemoglobin, fasting insulin and HOMA-IR. These results suggest that YKL-40 may be a major contributor to GDM.
Entities:
Keywords:
Gestational diabetes mellitus; YKL-40; oral glucose tolerance test