Doh Young Lee1, Min Woo Park2, Kyoung Ho Oh1, Jae-Gu Cho1, Soon-Young Kwon1, Jeong-Soo Woo1, Kwang Yoon Jung1, Seung-Kuk Baek1. 1. Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea. 2. Department of Otorhinolaryngology - Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, South Korea.
Abstract
BACKGROUND: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. METHODS: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. RESULTS: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). CONCLUSION: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.
BACKGROUND: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. METHODS: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. RESULTS: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). CONCLUSION: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.
Authors: Phillip Huyett; Umamaheswar Duvvuri; Robert L Ferris; Jonas T Johnson; Barry M Schaitkin; Seungwon Kim Journal: Otolaryngol Head Neck Surg Date: 2018-01-16 Impact factor: 3.497
Authors: Mateusz Szewczyk; Paweł Golusiński; Jakub Pazdrowski; Piotr Pieńkowski; Sławomir Marszałek; Jacek Sygut; Wojciech Golusiński Journal: Rep Pract Oncol Radiother Date: 2018-06-23