BACKGROUND: Patients with colorectal cancer are often excluded from clinical trials based on age or a poor performance score. However, 70% of colorectal cancer is diagnosed in patients over 65. Evaluation on the influence of age and comorbidity on survival and cause of death in a non-selected population. METHODS: Included were 621 consecutive patients with colorectal cancer. An extensive chart review was performed for 392 patients with colon cancer and 143 patients with rectal cancer. Analyses were performed separately for both groups. RESULTS: Median survival of colon cancer patients was 5.13 years, 131 patients (34.3%) died from tumour progression. Age and comorbidity were significant predictors for overall survival (P<0.001). Age was also a significant predictor of cause of death (P=0.001). In rectal cancer patients median survival was 4.67 years, 51 (35.7%) of patients died from tumour progression. Neither age nor comorbidity was significant predictors of survival. Age was a significant predictor of cause of death (P<0.001). CONCLUSIONS: In colon cancer patient age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis defining illness in the majority of patients. In rectal cancer patients neither age or comorbidity significantly impacted survival.
BACKGROUND:Patients with colorectal cancer are often excluded from clinical trials based on age or a poor performance score. However, 70% of colorectal cancer is diagnosed in patients over 65. Evaluation on the influence of age and comorbidity on survival and cause of death in a non-selected population. METHODS: Included were 621 consecutive patients with colorectal cancer. An extensive chart review was performed for 392 patients with colon cancer and 143 patients with rectal cancer. Analyses were performed separately for both groups. RESULTS: Median survival of colon cancerpatients was 5.13 years, 131 patients (34.3%) died from tumour progression. Age and comorbidity were significant predictors for overall survival (P<0.001). Age was also a significant predictor of cause of death (P=0.001). In rectal cancerpatients median survival was 4.67 years, 51 (35.7%) of patients died from tumour progression. Neither age nor comorbidity was significant predictors of survival. Age was a significant predictor of cause of death (P<0.001). CONCLUSIONS: In colon cancerpatient age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis defining illness in the majority of patients. In rectal cancerpatients neither age or comorbidity significantly impacted survival.
Authors: Hanna K Sanoff; William R Carpenter; Til Stürmer; Richard M Goldberg; Christopher F Martin; Jason P Fine; Nadine Jackson McCleary; Jeffrey A Meyerhardt; Joyce Niland; Katherine L Kahn; Maria J Schymura; Deborah Schrag Journal: J Clin Oncol Date: 2012-06-04 Impact factor: 44.544
Authors: Stefano Marventano; Giuseppe Grosso; Antonio Mistretta; Marta Bogusz-Czerniewicz; Roberta Ferranti; Francesca Nolfo; Gabriele Giorgianni; Stefania Rametta; Filippo Drago; Francesco Basile; Antonio Biondi Journal: Int J Colorectal Dis Date: 2014-07-27 Impact factor: 2.571
Authors: Anasooya Abraham; Elizabeth B Habermann; David A Rothenberger; Mary Kwaan; Armin D Weinberg; Helen M Parsons; Pankaj Gupta; Waddah B Al-Refaie Journal: Cancer Date: 2012-07-17 Impact factor: 6.860
Authors: Scott R Steele; Grace E Park; Eric K Johnson; Matthew J Martin; Alexander Stojadinovic; J A Maykel; Marlin W Causey Journal: Dis Colon Rectum Date: 2014-03 Impact factor: 4.585
Authors: Wijnanda J Frenkel; Erika J Jongerius; Miranda J Mandjes-van Uitert; Barbara C van Munster; Sophia E de Rooij Journal: J Am Geriatr Soc Date: 2014-01-21 Impact factor: 5.562
Authors: Aaron C Spaulding; Hanadi Hamadi; Osayande Osagiede; Riccardo Lemini; Jordan J Cochuyt; John Watson; James M Naessens; Dorin T Colibaseanu Journal: J Robot Surg Date: 2020-09-02
Authors: Nadine J McCleary; Sui Zhang; Chao Ma; Fang-Shu Ou; Tiffany M Bainter; Alan P Venook; Donna Niedzwiecki; Heinz-Josef Lenz; Federico Innocenti; Bert H O'Neil; Blase N Polite; Howard S Hochster; James N Atkins; Richard M Goldberg; Kimmie Ng; Robert J Mayer; Charles D Blanke; Eileen M O'Reilly; Charles S Fuchs; Jeffrey A Meyerhardt Journal: J Geriatr Oncol Date: 2022-01-31 Impact factor: 3.929