Literature DB >> 26695741

One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process.

Daniel J Leng1, Conor M Black1, Graham Pattison1.   

Abstract

Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

Entities:  

Year:  2016        PMID： 26695741     DOI： 10.1039/c5ob02468d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  9 in total

1.  Controlling the Cleavage of Carbon-Carbon Bonds To Generate α,α-Difluorobenzyl Carbanions for the Construction of Difluoromethylbenzenes.

Authors:  Hari R Khatri; Changho Han; Erica Luong; Xiaoliang Pan; Amna T Adam; Maali D Alshammari; Yihan Shao; David A Colby
Journal:  J Org Chem       Date:  2019-09-06       Impact factor: 4.354

2.  Conversion of Methyl Ketones and Methyl Sulfones into α-Deutero-α,α-Difluoromethyl Ketones and α-Deutero-α,α-Difluoromethyl Sulfones in Three Synthetic Steps.

Authors:  Munia F Sowaileh; Changho Han; Robert A Hazlitt; Eun Hoo Kim; Jinu P John; David A Colby
Journal:  Tetrahedron Lett       Date:  2016-12-21       Impact factor: 2.415

3.  Generation of Magnesium Pentafluoropropen-2-olate from Hexafluoroisopropanol and Synthesis of 2,2,4,4,4-Pentafluoro-3,3-dihydroxyketones.

Authors:  Robert A Hazlitt; Que-Lynn Tran; Munia F Sowaileh; David A Colby
Journal:  J Org Chem       Date:  2017-01-31       Impact factor: 4.354

4.  Magnesium-Promoted Additions of Difluoroenolates to Unactivated Imines.

Authors:  Alex L Nguyen; Hari R Khatri; James R Woods; Cassidy S Baldwin; Frank R Fronczek; David A Colby
Journal:  J Org Chem       Date:  2018-02-27       Impact factor: 4.354

5.  Gold-catalyzed Fluorination of Alkynyl Esters and Ketones: Efficient Access to Fluorinated 1,3-Dicarbonyl Compounds.

Authors:  Xiaojun Zeng; Zhichao Lu; Shiwen Liu; Gerald B Hammond; Bo Xu
Journal:  Adv Synth Catal       Date:  2017-10-05       Impact factor: 5.837

6.  Aromatic fluorocopolymers based on α-(difluoromethyl)styrene and styrene: synthesis, characterization, and thermal and surface properties.

Authors:  Joanna Wolska; Justyna Walkowiak-Kulikowska; Anna Szwajca; Henryk Koroniak; Bruno Améduri
Journal:  RSC Adv       Date:  2018-12-17       Impact factor: 4.036

7.  Conformational preferences of α-fluoroketones may influence their reactivity.

Authors:  Graham Pattison
Journal:  Beilstein J Org Chem       Date:  2017-12-29       Impact factor: 2.883

8.  Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics.

Authors:  Joseph L Howard; Michael C Brand; Duncan L Browne
Journal:  Angew Chem Int Ed Engl       Date:  2018-11-08       Impact factor: 15.336

9.  Enolization rates control mono- versus di-fluorination of 1,3-dicarbonyl derivatives.

Authors:  Neshat Rozatian; Andrew Beeby; Ian W Ashworth; Graham Sandford; David R W Hodgson
Journal:  Chem Sci       Date:  2019-09-16       Impact factor: 9.825
  9 in total

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