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Literature DB >> 26695434

Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo.

Steven A Castleberry^1,2,3,4, Benjamin D Almquist^1,2,3, Wei Li^1,2, Tiago Reis¹, John Chow¹, Sarah Mayner¹, Paula T Hammond^1,2,3.

Abstract

The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed.

Entities: Chemical Disease Gene Species

Keywords: controlled local delivery; diabetic wound healing; layer-by-layer; polymer coatings; siRNA delivery

Mesh：

Substances：

Year: 2015 PMID： 26695434 DOI： 10.1002/adma.201503565

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

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Cited

33 in total

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Authors: Juan M Colazo; Brian C Evans; Angel F Farinas; Salam Al-Kassis; Craig L Duvall; Wesley P Thayer
Journal: Tissue Eng Part B Rev Date: 2019-08 Impact factor: 6.389

2. Cytochrome P450 (CYP) epoxygenases as potential targets in the management of impaired diabetic wound healing.

Authors: Huichen Zhao; Jicui Chen; Jiachao Chai; Yuchao Zhang; Cong Yu; Zhe Pan; Peng Gao; Chen Zong; Qingbo Guan; Yuqin Fu; Yuantao Liu
Journal: Lab Invest Date: 2017-03-20 Impact factor: 5.662

3. A strain-programmed patch for the healing of diabetic wounds.

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Journal: Nat Biomed Eng Date: 2022-07-04 Impact factor: 29.234

4. A design approach for layer-by-layer surface-mediated siRNA delivery.

Authors: Jonathan J Chou; Adam G Berger; Sasan Jalili-Firoozinezhad; Paula T Hammond
Journal: Acta Biomater Date: 2021-09-01 Impact factor: 10.633

Review 5. Nanotechnology-Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID-19 Vaccines.

Authors: Chiara Rinoldi; Seyed Shahrooz Zargarian; Pawel Nakielski; Xiaoran Li; Anna Liguori; Francesca Petronella; Dario Presutti; Qiusheng Wang; Marco Costantini; Luciano De Sio; Chiara Gualandi; Bin Ding; Filippo Pierini
Journal: Small Methods Date: 2021-07-28

6. Functional characterisation of bioactive peptide derived from terrestrial snail Cryptozona bistrialis and its wound-healing property in normal and diabetic-induced Wistar albino rats.

Authors: Selvakumari Ulagesan; Kamatchi Sankaranarayanan; Amutha Kuppusamy
Journal: Int Wound J Date: 2018-02-26 Impact factor: 3.315

7. Acceleration of Diabetic Wound Healing with PHD2- and miR-210-Targeting Oligonucleotides.

Authors: Anne Dallas; Artem Trotsyuk; Heini Ilves; Clark A Bonham; Melanie Rodrigues; Karl Engel; Janos A Barrera; Nina Kosaric; Zachary A Stern-Buchbinder; Aleksandr White; Kenneth J Mandell; Paula T Hammond; Jonathan Mansbridge; Sumedha Jayasena; Geoffrey C Gurtner; Brian H Johnston
Journal: Tissue Eng Part A Date: 2018-06-29 Impact factor: 3.845