Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Pharmacokinetics of the antidepressant rolipram in healthy volunteers.

Literature DB >> 2669364

Pharmacokinetics of the antidepressant rolipram in healthy volunteers.

Abstract

1. The pharmacokinetics of rolipram were studied in healthy male volunteers using 3H-rolipram and a radioimmunoassay for measurement of unchanged drug. 2. Rolipram was rapidly and completely absorbed after an oral dose of 1 mg. Bioavailability was 73%. 3. Plasma levels of the unchanged drug declined with a terminal half-life of 2 h. The total clearance of rolipram was 2 ml/min per kg. 4. Labelled rolipram was excreted rapidly and completely. The main route of elimination was via the urine.

Entities: Chemical

Mesh：

Substances：

Year: 1989 PMID： 2669364 DOI： 10.3109/00498258909042306

Source DB: PubMed Journal: Xenobiotica ISSN： 0049-8254 Impact factor: 1.908

Keyword Cloud
Cited

7 in total

Review 1. Dealing with sadness, madness and hostility. New psychotropic drug remedies for the future.

Authors: A J Loonen
Journal: Pharm Weekbl Sci Date: 1992-08-21

2. Investigations on the percutaneous absorption of the antidepressant rolipram in vitro and in vivo.

Authors: J Hadgraft; S Hill; M Hümpel; L R Johnston; L R Lever; R Marks; T M Murphy; C Rapier
Journal: Pharm Res Date: 1990-12 Impact factor: 4.200

3. Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV.

Authors: Y Tsuboi; S J Shankland; J P Grande; H J Walker; R J Johnson; T P Dousa
Journal: J Clin Invest Date: 1996-07-15 Impact factor: 14.808

4. Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses.

Authors: David R Sprague; Masahiro Fujita; Yong Hoon Ryu; Jeih-San Liow; Victor W Pike; Robert B Innis
Journal: Nucl Med Biol Date: 2008-05 Impact factor: 2.408

Pharmacokinetics of the antidepressant rolipram in healthy volunteers.

Review 1. Dealing with sadness, madness and hostility. New psychotropic drug remedies for the future.

2. Investigations on the percutaneous absorption of the antidepressant rolipram in vitro and in vivo.

3. Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV.

4. Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses.

5. Pharmacokinetics of (+)-rolipram and (-)-rolipram in healthy volunteers.

6. Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.

Review 7. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders.