F S Sarfo1, J Akassi1, N K B Antwi2, V Obese2, S Adamu2, A Akpalu3, G Bedu-Addo1. 1. Kwame Nkrumah University of Science and Technology, Kumasi, Ghana ; Komfo Anokye Teaching Hospital, Kumasi, Ghana. 2. Komfo Anokye Teaching Hospital, Kumasi, Ghana. 3. Korle-Bu Teaching Hospital, Accra, Ghana.
Abstract
BACKGROUND: Although a direct causal relationship between hyperuricaemia and stroke continues to be debated, strong associations between serum uric acid (SUA) and cerebrovascular disease exist. Very few studies have been conducted to evaluate the frequency and association between this potentially modifiable biomarker of vascular risk and stroke in sub-Saharan Africa. Therefore the aim of this study was to examine the association between hyperuricaemia and the traditional risk factors and the outcomes of stroke in Ghanaian patients. METHODS: In this prospective observational study, 147 patients presenting with stroke at a tertiary referral centre in Ghana were consecutively recruited. Patients were screened for vascular risk factors and SUA concentrations measured after an overnight fast. Associations between hyperuricaemia and stroke outcomes were analysed using Kaplan-Meier and Cox proportional hazards regression analysis. RESULTS: The frequency of hyperuricaemia among Ghanaian stroke patients was 46.3%. Non-significant associations were observed between hyperuricaemia and the traditional risk factors of stroke. SUA concentration was positively correlated with stroke severity and associated with early mortality after an acute stroke with unadjusted hazards ratio of 2.3 (1.4 - 4.2, p=0.001). A potent and independent dose-response association between increasing SUA concentration and hazard of mortality was found on Cox proportional hazards regression, aHR (95% CI) of 1.65 (1.14-2.39), p=0.009 for each 100µmol/l increase in SUA. CONCLUSIONS: Hyperuricaemia is highly frequent and associated with adverse functional outcomes among Ghanaian stroke patients. Further studies are warranted to determine whether reducing SUA levels after a stroke would be beneficial within our setting.
BACKGROUND: Although a direct causal relationship between hyperuricaemia and stroke continues to be debated, strong associations between serum uric acid (SUA) and cerebrovascular disease exist. Very few studies have been conducted to evaluate the frequency and association between this potentially modifiable biomarker of vascular risk and stroke in sub-Saharan Africa. Therefore the aim of this study was to examine the association between hyperuricaemia and the traditional risk factors and the outcomes of stroke in Ghanaian patients. METHODS: In this prospective observational study, 147 patients presenting with stroke at a tertiary referral centre in Ghana were consecutively recruited. Patients were screened for vascular risk factors and SUA concentrations measured after an overnight fast. Associations between hyperuricaemia and stroke outcomes were analysed using Kaplan-Meier and Cox proportional hazards regression analysis. RESULTS: The frequency of hyperuricaemia among Ghanaian strokepatients was 46.3%. Non-significant associations were observed between hyperuricaemia and the traditional risk factors of stroke. SUA concentration was positively correlated with stroke severity and associated with early mortality after an acute stroke with unadjusted hazards ratio of 2.3 (1.4 - 4.2, p=0.001). A potent and independent dose-response association between increasing SUA concentration and hazard of mortality was found on Cox proportional hazards regression, aHR (95% CI) of 1.65 (1.14-2.39), p=0.009 for each 100µmol/l increase in SUA. CONCLUSIONS: Hyperuricaemia is highly frequent and associated with adverse functional outcomes among Ghanaian strokepatients. Further studies are warranted to determine whether reducing SUA levels after a stroke would be beneficial within our setting.
Authors: J R Crouse; J F Toole; W M McKinney; M B Dignan; G Howard; F R Kahl; M R McMahan; G H Harpold Journal: Stroke Date: 1987 Nov-Dec Impact factor: 7.914
Authors: John Kanellis; Susumu Watanabe; Jin H Li; Duk Hee Kang; Ping Li; Takahiko Nakagawa; Ann Wamsley; David Sheikh-Hamad; Hui Y Lan; Lili Feng; Richard J Johnson Journal: Hypertension Date: 2003-05-12 Impact factor: 10.190
Authors: Yacouba N Mapoure; Chia Mark Ayeah; M S Doualla; H Ba; Hugo B Mbatchou Ngahane; Salomon Mbahe; Henry N Luma Journal: Stroke Res Treat Date: 2017-09-10
Authors: Yacouba Njankouo Mapoure; Chia Mark Ayeah; Hamadou Ba; Hugo Bertrand Mbatchou Ngahane; Romuald Hentchoya; Henry Namme Luma Journal: Pan Afr Med J Date: 2019-04-09