Joohae Kim1, Nakwon Kwak1, Ha Youn Lee1, Taek Soo Kim2, Chang-Ki Kim3, Sung Koo Han1, Jae-Joon Yim4. 1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul 110-744, Republic of Korea. 2. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. 3. Molecular Mycobacteriology Unit, Korean Institute of Tuberculosis, Seoul, Korea. 4. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul 110-744, Republic of Korea. Electronic address: yimjj@snu.ac.kr.
Abstract
OBJECTIVE: Negative conversion of sputum culture is a useful marker for predicting treatment outcome and relapse of pulmonary tuberculosis (TB). The effect of drug resistance on negative conversion of sputum culture with treatment was evaluated in this study. METHODS: A total of 535 patients with culture-proven pulmonary TB were classified into three groups: drug-susceptible (DS), other drug-resistant (ODR), and multidrug-resistant/extensively drug-resistant (MDR/XDR). Rates of conversion of sputum culture at 4, 8, and 12 weeks were compared. RESULTS: At 4 weeks of treatment, the conversion rate in the DS group (52.7%) was higher than that in the ODR group (30.8%, p=0.003), but was not different compared with the MDR group (45.7%, p=0.427). At 8 weeks, the conversion rate in the DS group (76.3%) was higher than that in the ODR (63.5%, p=0.042) and MDR groups (60.0%, p=0.031). At 12 weeks, the conversion rate in the DS group (85.9%) tended to be higher than that in the MDR group (74.3%, p=0.062), but was not different from that in the ODR group (84.6%, p=0.796). CONCLUSION: The pattern of resistance to anti-TB drugs affects culture conversion rates in the early phase of treatment and also prolongs the time to culture conversion.
OBJECTIVE: Negative conversion of sputum culture is a useful marker for predicting treatment outcome and relapse of pulmonary tuberculosis (TB). The effect of drug resistance on negative conversion of sputum culture with treatment was evaluated in this study. METHODS: A total of 535 patients with culture-proven pulmonary TB were classified into three groups: drug-susceptible (DS), other drug-resistant (ODR), and multidrug-resistant/extensively drug-resistant (MDR/XDR). Rates of conversion of sputum culture at 4, 8, and 12 weeks were compared. RESULTS: At 4 weeks of treatment, the conversion rate in the DS group (52.7%) was higher than that in the ODR group (30.8%, p=0.003), but was not different compared with the MDR group (45.7%, p=0.427). At 8 weeks, the conversion rate in the DS group (76.3%) was higher than that in the ODR (63.5%, p=0.042) and MDR groups (60.0%, p=0.031). At 12 weeks, the conversion rate in the DS group (85.9%) tended to be higher than that in the MDR group (74.3%, p=0.062), but was not different from that in the ODR group (84.6%, p=0.796). CONCLUSION: The pattern of resistance to anti-TB drugs affects culture conversion rates in the early phase of treatment and also prolongs the time to culture conversion.
Authors: Ji Yeon Lee; Deog Kyeom Kim; Jung-Kyu Lee; Ho Il Yoon; Ina Jeong; Eunyoung Heo; Young Sik Park; Jae Ho Lee; Sung Soo Park; Sang-Min Lee; Chang-Hoon Lee; Jinwoo Lee; Sun Mi Choi; Jong Sun Park; Joon-Sung Joh; Young-Jae Cho; Yeon Joo Lee; Se Joong Kim; Young Ran Hwang; Hyeonjeong Kim; Jongeun Ki; Hyungsook Choi; Jiyeon Han; Heejung Ahn; Seokyung Hahn; Jae-Joon Yim Journal: Trials Date: 2017-02-13 Impact factor: 2.279