Literature DB >> 26692341

Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents.

Juan José Casal1, Mariela Bollini1, María Elisa Lombardo2, Ana María Bruno3.   

Abstract

A series of related thalidomide derivatives (2-9) were synthesized by microwave irradiation and evaluated for anti-inflammatory activity. Such activity was assessed in vivo and ex vivo. Compounds 2, 8 and 9 showed the highest levels of inhibition of TNF-α production. On rat paw edema and hyperalgesia assays, compound 9, (1,4-phthalazinedione) demonstrated the highest in vivo anti-inflammatory activity. Thus, compound 9 can be considered as a promising compound to be subjected to further modification to obtain new agents for the treatment of inflammatory diseases.

Entities:  

Keywords:  Anti-inflammatory effect; Phthalazinone derivate; Phthalimides; TNF-α

Mesh：

Substances：

Year:  2015        PMID： 26692341     DOI： 10.1016/j.ejps.2015.12.017

Source DB:  PubMed          Journal:  Eur J Pharm Sci        ISSN： 0928-0987            Impact factor:   4.384


  8 in total

1.  Tumor necrosis factor-α levels and non-surgical bleeding in continuous-flow left ventricular assist devices.

Authors:  Corey E Tabit; Mitchell J Coplan; Phetcharat Chen; Valluvan Jeevanandam; Nir Uriel; James K Liao
Journal:  J Heart Lung Transplant       Date:  2017-06-08       Impact factor: 10.247

2.  Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.

Authors:  Cindy Juliet Cristancho Ortiz; Matheus de Freitas Silva; Letizia Pruccoli; Nathália Fonseca Nadur; Luciana Luíza de Azevedo; Arthur Eugen Kümmerle; Isabella Alvim Guedes; Laurent Emmanuel Dardenne; Luiz Felipe Leomil Coelho; Marcos J Guimarães; Fernanda M R da Silva; Newton Castro; Vanessa Silva Gontijo; Viviana C T Rojas; Merelym Ketterym de Oliveira; Fabiana Cardoso Vilela; Alexandre Giusti-Paiva; Gisele Barbosa; Lídia Moreira Lima; Gabriela Beserra Pinheiro; Letícia Germino Veras; Márcia Renata Mortari; Andrea Tarozzi; Claudio Viegas
Journal:  RSC Med Chem       Date:  2022-03-17

Review 3.  Recent Advances in Host-Directed Therapies for Tuberculosis and Malaria.

Authors:  Kely C Matteucci; André A S Correa; Diego L Costa
Journal:  Front Cell Infect Microbiol       Date:  2022-05-20       Impact factor: 6.073

4.  Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool.

Authors:  Ambrin Farizah Babu; Susanne Csader; Ville Männistö; Milla-Maria Tauriainen; Heikki Pentikäinen; Kai Savonen; Anton Klåvus; Ville Koistinen; Kati Hanhineva; Ursula Schwab
Journal:  Sci Rep       Date:  2022-04-20       Impact factor: 4.996

5.  Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome.

Authors:  Rong-Jing Dong; Shi-Zhen Huang; Pratishtha Upadhyay; Samip Shrestha; Ya-Jie Zhai; Yu-Ye Li
Journal:  Front Med (Lausanne)       Date:  2020-01-21

Review 6.  Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis.

Authors:  Reto Guler; Mumin Ozturk; Solima Sabeel; Bongani Motaung; Suraj P Parihar; Friedrich Thienemann; Frank Brombacher
Journal:  Front Immunol       Date:  2021-10-20       Impact factor: 7.561

7.  Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter.

Authors:  Jialin Wang; Mi Huang; Jie Yang; Xinhua Ma; Sijian Zheng; Shihao Deng; Yun Huang; Xinzhou Yang; Ping Zhao
Journal:  Food Nutr Res       Date:  2017-08-23       Impact factor: 3.894

8.  Elucidation of the Mechanisms and Molecular Targets of Sanhuang Xiexin Decoction for Type 2 Diabetes Mellitus Based on Network Pharmacology.

Authors:  Manman Xu; Zhonghao Li; Lu Yang; Wujianwen Zhai; Nina Wei; Qiuyan Zhang; Bin Chao; Shijing Huang; Hanming Cui
Journal:  Biomed Res Int       Date:  2020-08-10       Impact factor: 3.411
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.