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Literature DB >> 26691834

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain.

Wenjie Ren¹, Maria Virginia Centeno¹, Sara Berger¹, Ying Wu², Xiaodong Na², Xianguo Liu², Jyothisri Kondapalli¹, A Vania Apkarian¹, Marco Martina¹, D James Surmeier¹.

Abstract

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

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Year: 2015 PMID： 26691834 PMCID： PMC4889808 DOI： 10.1038/nn.4199

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

24 in total

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