| Literature DB >> 26690974 |
Miu Shan Chan1,2, Dick Yan Tam1,2, Ziwen Dai1,2, Ling Sum Liu1,2, Jonathan Weng-Thim Ho3, Man Lee Chan1, Di Xu4, Man Shing Wong4, Chung Tin3, Pik Kwan Lo1,2.
Abstract
The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers.Entities:
Keywords: DNA nanocarriers; anticancer drugs; delivery; lipophilic molecules; mitochondria
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Year: 2015 PMID： 26690974 DOI： 10.1002/smll.201503051
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281